Hard Drives can just sometimes corrupt. There's also a chance that the directory that Dolphin searches for has changed? Not entirely sure what else can be done, might wanna post pictures of what's going on.
"NintenDON'T sue me please haha"
I was playing the Wind Waker ROM with Dolphin the other day, and when I tried to launch it, it was gone. The only thing that remains of it is a corrupted ISO file. I'm confused and concerned. Help?