Game region differences

I've been going through an getting my old games for the Wii and been downloading the USA ones as I know that will give me english and is probably the version I would get if I bought the game. Coming to Skylanders however the is a USA version and an Australia/Europe version. I'm based in Australia but wouldn't know what the differences are between them. All my other downloads have been USA but I probably had the Aus/Eur version when I bought them physically. Would it matter which version or not really?