| Title | Region | Version | Languages | Rating |
| Safari Adventures: Africa |  | 1.00 | - | 4.0 |
| Safecracker | | 1.00 | - | 6.5 |
| Saint | | 1.00 | - | 4.5 |
| Sakura Wars: So Long, My Love | | 1.00 | - | 8.6 |
| Sam & Max: Beyond Time and Space | | 1.00 | en es fr | 9.4 |
| Sam & Max: Season One | | 1.00 | en es fr | 8.6 |
| Samba de Amigo | | 1.00 | en es fr | 9.1 |
| Samurai Shodown Anthology | | 1.00 | - | 9.2 |
| Samurai Warriors 3 | | 1.00 | en es fr | 9.2 |
| Samurai Warriors: Katana | | 1.00 | - | 6.3 |
| Santa Claus Is Comin' to Town! | | 1.00 | - | 6.6 |
| Satisfashion: Rock the Runway | | 1.00 | - | 5.5 |
| Scarface: The World Is Yours | | 1.00 | - | 8.6 |
| Scene It Bright Lights! Big Screen! | | 1.00 | - | 8.8 |
| Scene It Twilight | | 1.00 | en es fr | 8.0 |
| Science Papa | | 1.00 | en fr | 9.3 |
| Scooby-Doo! and the Spooky Swamp | | 1.00 | en es fr | 8.5 |
Scooby-Doo! First Frights  | | 1.00 | en es fr | 8.6 |
| Score International Baja 1000: The Official Game | | 1.00 | - | 7.5 |
| Sea Monsters: A Prehistoric Adventure | | 1.00 | - | 7.8 |
| Secret Files: Tunguska | | 1.00 | - | 9.0 |
| Secret Saturdays, The: Beasts of the 5th Sun | | 1.00 | en es fr | 7.0 |
| Sega Bass Fishing | | 1.00 | - | 8.2 |
| Sega Superstars Tennis | | 1.00 | en es fr | 8.5 |
| Sengoku Basara: Samurai Heroes | | 1.00 | en es fr | 9.0 |
| Sesame Street: Cookie's Counting Carnival - The Videogame | | 1.00 | - | 6.5 |
| Sesame Street: Elmo's A-to-Zoo Adventure - The Videogame | | 1.00 | - | 5.3 |
| Sesame Street: Elmo's Musical Monsterpiece - The Videogame | | 1.00 | en es | 5.4 |
| Sesame Street: Ready, Set, Grover! with Elmo - The Videogame | | 1.00 | en es | 6.0 |
| Shaun White Skateboarding | | 1.00 | en es fr | 9.0 |
| Shaun White Snowboarding: Road Trip | | 1.00 | en es fr | 8.0 |
| Shaun White Snowboarding: Road Trip (Target Limited Edition) | | 1.00 | en es fr | 8.0 |
| Shaun White Snowboarding: World Stage | | 1.00 | en es fr | 9.0 |
| Shawn Johnson Gymnastics | | 1.00 | en es fr | 1.0 |
| Shimano Xtreme Fishing | | 1.00 | - | 6.3 |
| Shiren the Wanderer | | 1.00 | - | 7.5 |
| Shonen Jump One Piece: Unlimited Adventure | | 1.00 | - | 8.2 |
| Showtime Championship Boxing | | 1.00 | - | 9.3 |
| Sid Meier's Pirates! | | 1.00 | en es fr | 8.6 |
| Silent Hill: Shattered Memories | | 1.00 | en es fr | 8.1 |
| SimAnimals | | 1.00 | en es fr | 7.7 |
| SimAnimals: Africa | | 1.00 | en fr | 8.8 |
| SimCity Creator | | 1.00 | en es fr | 8.4 |
| Simpsons Game, The | | 1.00 | - | 8.0 |
| Sims 2, The: Castaway | | 1.00 | - | 6.1 |
| Sims 2, The: Pets | | 1.00 | - | 8.4 |
| Sims 3, The | | 1.00 | en es fr | 7.6 |
| Sin & Punishment: Star Successor | | 1.00 | - | 8.9 |
| Sing 4: The Hits Edition | | 1.00 | en es fr | 5.5 |
| Six Flags Fun Park | | 1.10 | en fr | 7.4 |
| Skate City Heroes | | 1.00 | - | 6.5 |
| Skate It | | 1.00 | en es fr | 8.7 |
| Ski and Shoot | | 1.00 | en fr | 5.5 |
| Ski-Doo Snowmobile Challenge | | 1.00 | en fr | 10.0 |
| Sky Crawlers, The: Innocent Aces | | 1.00 | en es fr | 9.2 |
| Skylanders: Giants | | 1.00 | en fr | 8.4 |
| Skylanders: Spyro's Adventure | | 1.10 | en fr | 8.3 |
| Skylanders: SuperChargers Racing | | 1.00 | en es fr pt | 7.6 |
| Skylanders: Swap Force | | 1.10 | en fr | 8.2 |
| Skylanders: Trap Team | | 1.10 | en fr | 8.4 |
| Sled Shred featuring the Jamaican Bobsled Team | | 1.00 | en es fr | 6.5 |
| Sleepover Party | | 1.00 | en es fr | 3.3 |
| Smart Series Presents: Jaja's Adventure | | 1.00 | - | 5.5 |
| Smarty Pants: Trivia Fun for Everyone! | | 1.00 | - | 6.8 |
| Smiley World: Island Challenge | | 1.00 | en es fr | 7.5 |
| Smurfs 2, The | | 1.00 | en es fr | 5.4 |
| Smurfs, The: Dance Party | | 1.00 | - | 6.6 |
| Smurfs, The: Dance Party (Toys R Us) | | 1.00 | - | 6.2 |
| Sniper Elite | | 1.00 | en es fr | 8.8 |
| SNK Arcade Classics Vol. 1 | | 1.00 | - | 8.6 |
| Solitaire & Mahjong | | 1.00 | - | 2.2 |
| Sonic & Sega All-Stars Racing | | 1.00 | en es fr | 7.7 |
| Sonic and the Black Knight | | 1.00 | de en es fr it ja | 7.6 |
| Sonic and the Secret Rings | | 1.00 | de en es fr it ja | 6.6 |
| Sonic Colors | | 1.00 | de en es fr it ja | 8.3 |
| Sonic Riders: Zero Gravity | | 1.00 | de en es fr it ja | 8.4 |
| Sonic Unleashed | | 1.00 | de en es fr it ja | 7.9 |
| Soulcalibur Legends | | 1.00 | - | 7.3 |
| Space Camp | | 1.00 | en fr | 3.2 |
| Space Chimps | | 1.00 | en fr | 8.2 |
| Spectrobes: Origins | | 1.00 | - | 9.3 |
| Speed | | 1.00 | en es fr | 7.7 |
| Speed Racer: The Videogame | | 1.00 | en es fr pt | 9.2 |
| Speed Zone | | 1.00 | - | 6.7 |
| Spider-Man 3 | | 1.00 | - | 7.6 |
| Spider-Man: Edge of Time | | 1.00 | en fr | 8.7 |
| Spider-Man: Friend or Foe | | 1.00 | - | 8.3 |
| Spider-Man: Shattered Dimensions | | 1.00 | - | 8.5 |
| Spider-Man: Web of Shadows | | 1.00 | en fr | 8.4 |
| Spiderwick Chronicles, The | | 1.00 | - | 7.0 |
| Spore Hero | | 1.00 | en es fr | 8.2 |
| SPRay | | 1.00 | - | 5.6 |
| Spy Fox in Dry Cereal | | 1.00 | - | 8.8 |
| Spy Games: Elevator Mission | | 1.00 | - | 5.0 |
| Spyborgs | | 1.00 | en es fr | 9.0 |
| Squeeballs Party | | 1.00 | en es fr | 7.5 |
| SSX Blur | | 1.00 | en fr | 5.0 |
| Star Trek: Conquest | | 1.00 | - | 8.2 |
| Star Wars: The Clone Wars - Lightsaber Duels | | 1.00 | en fr | 8.9 |
| Star Wars: The Clone Wars - Republic Heroes | | 1.00 | en es fr | 6.6 |
| Star Wars: The Force Unleashed | | 1.00 | en fr | 9.3 |
| Star Wars: The Force Unleashed II | | 1.00 | en es fr | 7.9 |
| Story Hour: Adventures | | 1.00 | en es | 6.0 |
| Story Hour: Fairy Tales | | 1.00 | en es fr | 7.5 |
| Storybook Workshop | | 1.00 | en es fr | none |
| Summer Athletics: The Ultimate Challenge | | 1.00 | en es fr | none |
| Summer Sports 2: Island Sports Party | | 1.00 | - | 6.0 |
| Summer Sports: Paradise Island | | 1.00 | - | 2.3 |
| Summer Stars 2012 | | 1.00 | en es fr | none |
| Super Fruit Fall | | 1.00 | - | none |
| Super Mario All-Stars | | 1.00 | - | 7.3 |
| Super Mario Galaxy | | 1.00 | en es fr | 8.7 |
| Super Mario Galaxy 2 | | 1.00 | en es fr | 8.7 |
| Super Monkey Ball: Banana Blitz | | 1.00 | - | 8.4 |
| Super Monkey Ball: Step & Roll | | 1.00 | - | 7.6 |
| Super Paper Mario | | 1.20 | - | 8.7 |
| Super PickUps | | 1.00 | en es fr | 4.0 |
| Super Smash Bros. Brawl | | 1.20 | - | 8.7 |
| Super Sonic Racer | | 1.00 | en es fr | 2.9 |
| Super Swing Golf | | 1.00 | - | 7.8 |
| Super Swing Golf Season 2 | | 1.00 | - | 9.3 |
| Surf's Up | | 1.00 | en es fr | 6.4 |
| Survivor | | 1.00 | - | 5.5 |
| Swords | | 1.00 | - | 6.0 |
