| Title | Year | Publisher | Serial | Cart Size (MB) | Rating |
| EA Playground | 2007 | Electronic Arts | NTR-YPGE-USA | 64 | 4.0 |
| Easy Piano | 2010 | Valcon Games | NTR-BEPE-USA | 16 | none |
| Eco-Creatures: Save the Forest | 2008 | Majesco | NTR-AERE-USA | 16 | none |
| Ed, Edd n Eddy: Scam of the Century | 2007 | D3Publisher | NTR-A5OE-USA | 16 | 8.0 |
| Elebits: The Adventures of Kai and Zero | 2009 | Konami | NTR-YERE-USA | 64 | 9.0 |
| Electroplankton | 2006 | Nintendo | NTR-ATIE-USA | 16 | 8.1 |
| Elements of Destruction | 2007 | THQ | NTR-YEDE-USA | 8 | none |
| Elf Bowling 1 & 2 | 2005 | Ignition Entertainment | NTR-AEBE-USA | 8 | 9.3 |
| Elite Beat Agents | 2006 | Nintendo | NTR-AOSE-USA | 128 | 9.2 |
| Elite Forces: Unit 77 | 2009 | Deep Silver | NTR-CEFE-USA | 16 | none |
| Emergency Room: Real Life Rescues | 2009 | Legacy Interactive | NTR-CEJE-USA | 16 | none |
| Emergency! Disaster Rescue Squad | 2009 | Destineer | NTR-CIQE-USA | 32 | none |
| Emily the Strange: Strangerous | 2011 | Conspiracy Entertainment | TWL-VESE-USA | 64 | none |
| Emma at the Farm | 2008 | Aspyr | NTR-YM9E-USA | 16 | none |
| Emma in the Mountains | 2008 | Aspyr | NTR-YQVE-USA | 16 | none |
| Enchanted | 2007 | Disney Interactive Studios | NTR-YECE-USA | 32 | none |
| Ener-G: Dance Squad | 2008 | Ubisoft | NTR-CDSE-USA | 128 | 7.0 |
| Ener-G: Gym Rockets | 2008 | Ubisoft | NTR-CERE-USA | 32 | 10.0 |
| Ener-G: Horse Riders | 2008 | Ubisoft | NTR-CH4E-USA | 64 | none |
| Eragon | 2006 | Sierra Entertainment | NTR-AEGE-USA | 64 | 6.5 |
| Escape the Museum | 2009 | GameMill Publishing | NTR-BESE-USA | 64 | none |
| Etrian Odyssey | 2007 | Atlus | NTR-AKYE-USA | 16 | 8.6 |
| Etrian Odyssey II: Heroes of Lagaard | 2008 | Atlus | NTR-YIKE-USA | 32 | 9.3 |
| Etrian Odyssey III: The Drowned City | 2010 | Atlus | NTR-BJ3E-USA | 64 | 9.2 |
| Exit DS | 2008 | Square Enix | NTR-YEXE-USA | 32 | 10.0 |
