| Safari Adventures: Africa | 2009 | Conspiracy Entertainment | NTR-CSAE-USA | 16 | 7.0 |
| Safecracker: The Ultimate Puzzle Challenge! | 2009 | Dreamcatcher | NTR-BSIE-USA | 64 | none |
| Sally's Salon | 2008 | Capcom | NTR-CSIE-USA | 16 | none |
| Salon Superstar | 2009 | 505 Games | NTR-C39E-USA | 32 | none |
| Samantha Swift and the Hidden Roses of Athena | 2010 | MumboJumbo | NTR-BHRE-USA | 32 | none |
| Sands of Destruction | 2010 | Sega | NTR-YSLE-USA | 256 | 9.6 |
| Santa Claus is Comin' to Town | 2011 | Crave | NTR-BX7E-USA | 16 | 7.8 |
| Sarah: Keeper of the Unicorn | 2009 | Dreamcatcher | NTR-YSAE-USA | 16 | 10.0 |
| Satisfashion: Rock the Runway | 2010 | Destineer | NTR-BS5E-USA | 16 | none |
| SBK: Snowboard Kids | 2005 | Atlus | NTR-ASBE-USA | 64 | 7.5 |
| Scene It? Twilight | 2010 | Konami | NTR-BT8E-USA | 128 | 5.5 |
| Science Papa | 2009 | Activision | NTR-BSNE-USA | 32 | 7.0 |
| Scooby-Doo! and the Spooky Swamp | 2010 | Warner Bros. Interactive Entertainment | NTR-BJ2E-USA | 64 | 9.6 |
| Scooby-Doo! First Frights | 2009 | Warner Bros. Interactive Entertainment | NTR-CQVE-USA | 64 | 7.0 |
| Scooby-Doo! Unmasked | 2005 | THQ | NTR-ASDE-USA | 16 | 5.5 |
| Scooby-Doo! Who's Watching Who | 2006 | THQ | NTR-AC6E-USA | 16 | 8.3 |
| Scrabble: Crossword Game | 2009 | Scrabble | NTR-CVXE-USA | 64 | none |
| Scribblenauts | 2009 | Warner Bros. Interactive Entertainment | NTR-BSLE-USA | 32 | 9.3 |
| Scribblenauts Collection | 2013 | Warner Bros. Interactive Entertainment | NTR-TCSE-USA | 64 | 9.0 |
| Scripps Spelling Bee | 2010 | THQ | TWL-VSPE-USA | 32 | none |
| Scurge: Hive | 2006 | SouthPeak Games | NTR-AHVE-USA | 16 | none |
| Sea Monsters: A Prehistoric Adventure | 2008 | DSI Games | NTR-YS3E-USA | 8 | 10.0 |
| Sea Park Tycoon | 2010 | Destineer | NTR-C6TE-USA | 16 | none |
| Secret Files: Tunguska | 2010 | Deep Silver | NTR-YGSE-USA | 64 | 9.0 |
| Secret Saturdays, The: Beasts of the 5th Sun | 2009 | D3Publisher | NTR-BSYE-USA | 32 | none |
| Sega Casino | 2005 | Sega | NTR-ACAE-USA | 8 | none |
| Sega Superstars Tennis | 2008 | Sega | NTR-YT7E-USA | 64 | none |
| Sesame Street: Elmo's Musical Monsterpiece | 2012 | Warner Bros. Interactive Entertainment | NTR-B6LE-USA | 128 | none |
| Settlers, The | 2007 | Ubisoft | NTR-AUZE-USA | 64 | 10.0 |
| Shamu's Deep Sea Adventures | 2005 | Activision | NTR-ABAE-USA | 32 | 5.5 |
| Shaun the Sheep | 2008 | D3Publisher | NTR-CSUE-USA | 32 | 10.0 |
| Shaun White Snowboarding | 2008 | Ubisoft | NTR-CU3E-USA | 32 | none |
| Shawn Johnson Gymnastics | 2010 | Zoo Games | NTR-BRVE-USA | 16 | none |
| Shepherd's Crossing 2 DS | 2010 | Graffiti Entertainment | NTR-BE2E-USA | 8 | 10.0 |
| Sherlock Holmes and the Mystery of Osborne House | 2011 | THQ | NTR-B46E-USA | 16 | none |
| Sherlock Holmes: The Mystery of the Mummy | 2009 | Dreamcatcher | NTR-CS6E-USA | 64 | none |
| Shin Megami Tensei: Devil Survivor | 2009 | Atlus | NTR-CVIE-USA | 64 | 9.4 |
| Shin Megami Tensei: Devil Survivor 2 | 2012 | Atlus | NTR-TDVE-USA | 128 | 9.3 |
| Shin Megami Tensei: Strange Journey | 2010 | Atlus | NTR-BMTE-USA | 128 | 9.5 |
| Shining Stars: Super Starcade | 2008 | DSI Games | NTR-CS2E-USA | 8 | none |
| Shorts | 2009 | Majesco | NTR-BSHE-USA | 32 | none |
| Showtime Championship Boxing | 2007 | DSI Games | NTR-YSYE-USA | 16 | none |
| Shrek the Third | 2007 | Activision | NTR-A3SE-USA | 32 | 8.7 |
| Shrek's Carnival Craze: Party Games | 2008 | Activision | NTR-CLZE-USA | 64 | 8.5 |
| Shrek: Forever After | 2010 | Activision | TWL-VSKE-USA | 64 | 8.9 |
| Shrek: Ogres & Dronkeys | 2007 | Activision | NTR-YQ3E-USA | 64 | 6.0 |
| Shrek: Smash n' Crash Racing | 2007 | Activision | NTR-A4IE-USA | 32 | 9.0 |
| Shrek: Super Slam | 2005 | Activision | NTR-AS3E-USA | 32 | 8.3 |
| Sid Meier's Civilization Revolution | 2008 | 2K Games | NTR-YS6E-USA | 64 | 8.0 |
| Sideswiped | 2009 | Majesco | NTR-BCLE-USA | 16 | 8.5 |
| Silly Bandz | 2010 | Zoo Games | NTR-BZEE-USA | 8 | 10.0 |
| Silverlicious | 2012 | GameMill Publishing | NTR-TASE-USA | 16 | 10.0 |
| SimAnimals | 2009 | Electronic Arts | NTR-CM3E-USA | 128 | none |
| SimAnimals: Africa | 2009 | Electronic Arts | NTR-C27E-USA | 128 | 8.0 |
| SimCity DS | 2007 | Electronic Arts | NTR-AC3E-USA | 64 | 7.8 |
| SimCity: Creator | 2008 | EA Games | NTR-YC2E-USA | 64 | 9.0 |
| Simpsons Game, The | 2007 | EA Games | NTR-YSZE-USA | 128 | 8.6 |
| Sims 2, The | 2005 | Electronic Arts | NTR-ASJE-USA | 64 | 7.5 |
| Sims 2, The: Apartment Pets | 2008 | Electronic Arts | NTR-CAPE-USA | 32 | none |
| Sims 2, The: Castaway | 2007 | Electronic Arts | NTR-YS2E-USA | 64 | 8.0 |
| Sims 2, The: Pets | 2006 | EA Games | NTR-A4OE-USA | 32 | none |
| Sims 3, The | 2010 | Electronic Arts | TWL-VS3E-USA | 128 | 5.9 |
| Six Flags Fun Park | 2008 | Brash Entertainment | NTR-CF6E-USA | 64 | none |
| Skate It | 2008 | Electronic Arts | NTR-CSVE-USA | 32 | 8.7 |
| Slingo Quest | 2008 | MumboJumbo | NTR-CSLE-USA | 8 | 5.5 |
| Smart Boy's Gameroom | 2007 | UFO Interactive | NTR-A2HE-USA | 16 | none |
| Smart Boy's Gameroom 2 | 2009 | UFO Interactive | NTR-BS3E-USA | 16 | none |
| Smart Boy's Toys Club | 2008 | UFO Interactive | NTR-CSXE-USA | 16 | none |
| Smart Boy's Winter Wonderland | 2008 | UFO Interactive | NTR-YITE-USA | 16 | none |
| Smart Girl's Magical Book Club | 2008 | Tommo | NTR-YI8E-USA | 64 | none |
| Smart Girl's Party Game | 2008 | UFO Interactive | NTR-CSYE-USA | 16 | none |
| Smart Girl's Playhouse | 2007 | UFO Interactive | NTR-A2IE-USA | 16 | none |
| Smart Girl's Playhouse 2 | 2009 | Tommo | NTR-BS4E-USA | 16 | none |
| Smart Girl's Playhouse Party | 2010 | UFO Interactive | NTR-BG7E-USA | 64 | none |
| Smart Girl's Winter Wonderland | 2008 | UFO Interactive | NTR-CWIE-USA | 16 | none |
| Smart Kid's Gameclub | 2007 | UFO Interactive | NTR-YIDE-USA | 32 | none |
| Smart Kid's Mega Game Mix | 2009 | UFO Interactive | NTR-BS2E-USA | 32 | none |
| Smart Kid's Party Fun Pak | 2008 | UFO Interactive | NTR-CSZE-USA | 32 | none |
| SmileyWorld: Island Challenge | | | | 8 | none |
| Smurfs 2, The | | | | 32 | none |
| Smurfs, The | | | | 32 | none |
| SNK vs. Capcom: Card Fighters DS | | | | 32 | 7.0 |
| Snood 2: On Vacation | | | | 8 | none |
| Solatorobo: Red the Hunter | | | | 64 | 9.1 |
| Solitaire Overload | | | | 8 | none |
| Solitaire Overload Plus | | | | 8 | none |
| Sonic & Sega All-Stars Racing | | | | 64 | 7.1 |
| Sonic Chronicles: The Dark Brotherhood | | | | 128 | 7.2 |
| Sonic Classic Collection | | | | 64 | 8.3 |
| Sonic Colors | | | | 64 | 7.3 |
| Sonic Rush | | | | 64 | 8.7 |
| Sonic Rush Adventure | | | | 64 | 8.3 |
| Sonny with a Chance | | | | 64 | none |
| Sorcerer's Apprentice, The | | | | 64 | none |
| Soul Bubbles | | | | 32 | 7.0 |
| Space Bust-A-Move | | | | 32 | none |
| Space Camp | | | | 32 | none |
| Space Chimps | | | | 64 | none |
| Space Invaders Extreme | | | | 64 | 9.0 |
| Space Invaders Extreme 2 | | | | 64 | 8.8 |
| Space Invaders Revolution | | | | 16 | 6.0 |
| Spanish for Everyone! | | | | 32 | 2.0 |
| Spectral Force: Genesis | | | | 64 | 7.0 |
| Spectrobes | | | | 64 | 8.1 |
| Spectrobes: Beyond the Portals | | | | 128 | 9.0 |
| Speed Racer: The Videogame | | | | 64 | 8.0 |
| Spelling Challenges and More! | | | | 8 | none |
| Spider-Man 2 | | | | 16 | none |
| Spider-Man 3 | | | | 64 | none |
| Spider-Man: Battle for New York | | | | 64 | none |
| Spider-Man: Edge of Time | | | | 64 | 7.7 |
| Spider-Man: Friend or Foe | | | | 64 | 10.0 |
| Spider-Man: Shattered Dimensions | | | | 64 | 9.4 |
| Spider-Man: Web of Shadows | | | | 64 | 9.2 |
| Spiderwick Chronicles, The | | | | 64 | none |
| Spitfire Heroes: Tales of the Royal Air Force | | | | 16 | none |
| SpongeBob SquarePants Featuring Nicktoons: Globs of Doom | | | | 32 | 7.5 |
| SpongeBob SquarePants: Creature from the Krusty Krab | | | | 32 | 6.0 |
| SpongeBob SquarePants: Plankton's Robotic Revenge | | | | 64 | 4.5 |
| SpongeBob SquarePants: The Yellow Avenger | | | | 32 | 6.3 |
| SpongeBob vs the Big One: Beach Party Cook-Off | | | | 64 | 7.0 |
| SpongeBob's Atlantis SquarePantis | | | | 32 | 9.2 |
| SpongeBob's Boating Bash | | | | 32 | 7.0 |
| SpongeBob's Truth or Square | | | | 32 | 8.0 |
| Spore Creatures | | | | 32 | 7.9 |
| Spore Hero Arena | | | | 64 | 7.0 |
| Sports Collection | | | | 32 | none |
| Sprung: A Game Where Everyone Scores | | | | 32 | 9.0 |
| Spy Kids: All the Time in the World | | | | 16 | 5.5 |
| Spyro: Shadow Legacy | | | | 64 | 5.8 |
| Squeeballs Party | | | | 32 | none |
| Squinkies 2: Adventure Mall Surprize! | | | | 32 | none |
| Squinkies: Surprize Inside | | | | 32 | none |
| Squishy Tank | | | | 16 | none |
| Star Fox Command | | | | 32 | 6.3 |
| Star Trek: Tactical Assault | | | | 16 | 7.0 |
| Star Wars: Battlefront - Elite Squadron | | | | 64 | 7.5 |
| Star Wars: Episode III - Revenge of the Sith | | | | 32 | 9.0 |
| Star Wars: Lethal Alliance | | | | 32 | none |
| Star Wars: The Clone Wars - Jedi Alliance | | | | 256 | 4.0 |
| Star Wars: The Clone Wars - Republic Heroes | | | | 128 | 9.0 |
| Star Wars: The Force Unleashed | | | | 64 | 9.0 |
| Star Wars: The Force Unleashed II | | | | 128 | 7.0 |
| Steal Princess | | | | 64 | 3.0 |
| Steel Horizon | | | | 32 | none |
| Stitch Jam | | | | 64 | 9.0 |
| Story of Noah's Ark, The | | | | 16 | 10.0 |
| Strawberry Shortcake: Strawberryland Games | | | | 16 | none |
| Strawberry Shortcake: The Four Seasons Cake | | | | 16 | none |
| Style Lab: Fashion Design | | | | 32 | none |
| Style Lab: Jewelry Design | | | | 32 | none |
| Style Lab: Makeover | | | | 32 | none |
| Style Savvy | | | | 128 | 9.4 |
| Sudoku Ball Detective | | | | 8 | none |
| Sudoku Gridmaster | | | | 8 | none |
| Sudoku Mania: Enhance Your Critical Thinking Skills! | | | | 8 | none |
| Sudokuro: Sudoku & Kakuro Games | | | | 8 | 1.0 |
| Suikoden: Tierkreis | | | | 256 | 9.2 |
| Suite Life of Zack & Cody, The: Circle of Spies | | | | 32 | none |
| Suite Life of Zack & Cody, The: Tipton Trouble | | | | 16 | none |
| Summon Night: Twin Age | | | | 128 | 10.0 |
| Super Black Bass Fishing | | | | 32 | none |
| Super Collapse! 3 | | | | 8 | none |
| Super Dodgeball Brawlers | | | | 8 | 8.5 |
| Super Fruit Fall | | | | 8 | none |
| Super Mario 64 DS | 2004 | | | 16 | 8.8 |
| Super Monkey Ball: Touch & Roll | | | | 64 | 8.3 |
| Super Princess Peach | | | | 32 | 8.9 |
| Super Robot Taisen OG Saga: Endless Frontier | | | | 128 | 8.7 |
| Super Scribblenauts | | | | 32 | 9.2 |
| Super Speed Machines | | | | 32 | 7.0 |
| Super Star Kartz | | | | 128 | none |
| Superman Returns | | | | 64 | 3.0 |
| Surf's Up | | | | 32 | none |
| Survivor | | | | 16 | none |
| Sushi Academy | | | | 16 | none |
| Sushi Go-Round | | | | 32 | none |
| Suzuki Super-Bikes II: Riding Challenge | | | | 16 | none |
