| Safari Adventures: Africa | | | | 16 | 7.0 |
| Safecracker: The Ultimate Puzzle Challenge! | | | | 64 | none |
| Sally's Salon | | | | 16 | none |
| Salon Superstar | | | | 32 | none |
| Samantha Swift and the Hidden Roses of Athena | | | | 32 | none |
| Sands of Destruction | | | | 256 | 10.0 |
| Santa Claus is Comin' to Town | | | | 16 | 7.0 |
| Sarah: Keeper of the Unicorn | | | | 16 | 10.0 |
| Satisfashion: Rock the Runway | | | | 16 | none |
| SBK: Snowboard Kids | | | | 64 | 7.5 |
| Scene It Twilight | | | | 128 | 5.5 |
| Science Papa | | | | 32 | none |
| Scooby-Doo! and the Spooky Swamp | | | | 64 | 9.6 |
| Scooby-Doo! First Frights | | | | 64 | 9.0 |
| Scooby-Doo! Unmasked | | | | 16 | 5.5 |
| Scooby-Doo! Who's Watching Who | | | | 16 | 8.3 |
| Scrabble: Crossword Game | | | | 64 | none |
| Scribblenauts | | | | 32 | 9.2 |
| Scribblenauts Collection | | | | 64 | 9.0 |
| Scripps Spelling Bee | | | | 32 | none |
| Scurge: Hive | | | | 16 | none |
| Sea Monsters: A Prehistoric Adventure | | | | 8 | 10.0 |
| Sea Park Tycoon | | | | 16 | none |
| Secret Files: Tunguska | | | | 64 | 9.0 |
| Secret Saturdays, The: Beasts of the 5th Sun | | | | 32 | none |
| Sega Casino | | | | 8 | none |
| Sega Superstars Tennis | | | | 64 | none |
| Sesame Street: Elmo's Musical Monsterpiece | | | | 128 | none |
| Settlers, The | | | | 64 | 10.0 |
| Shamu's Deep Sea Adventures | | | | 32 | 1.0 |
| Shaun the Sheep | | | | 32 | 10.0 |
| Shaun White Snowboarding | | | | 32 | none |
| Shawn Johnson Gymnastics | | | | 16 | none |
| Shepherd's Crossing 2 DS | | | | 8 | none |
| Sherlock Holmes and the Mystery of Osborne House | | | | 16 | none |
| Sherlock Holmes: The Mystery of the Mummy | | | | 64 | none |
| Shin Megami Tensei: Devil Survivor | | | | 64 | 9.3 |
| Shin Megami Tensei: Devil Survivor 2 | | | | 128 | 9.3 |
| Shin Megami Tensei: Strange Journey | | | | 128 | 9.5 |
| Shining Stars: Super Starcade | | | | 8 | none |
| Shorts | | | | 32 | none |
| Showtime Championship Boxing | | | | 16 | none |
| Shrek the Third | | | | 32 | 8.7 |
| Shrek's Carnival Craze: Party Games | | | | 64 | 8.2 |
| Shrek: Forever After | | | | 64 | 10.0 |
| Shrek: Ogres & Dronkeys | | | | 64 | 7.8 |
| Shrek: Smash n' Crash Racing | | | | 32 | 10.0 |
| Shrek: Super Slam | | | | 32 | 9.8 |
| Sid Meier's Civilization Revolution | | | | 64 | 8.0 |
| Sideswiped | | | | 16 | 8.5 |
| Sillybandz DS | | | | 8 | 10.0 |
| Silverlicious | | | | 16 | 10.0 |
| SimAnimals | | | | 128 | none |
| SimAnimals: Africa | | | | 128 | 8.0 |
| SimCity DS | | | | 64 | 7.3 |
| SimCity: Creator | | | | 64 | 8.5 |
| Simpsons Game, The | 2007 | | | 128 | 9.8 |
| Sims 2, The | | | | 64 | 7.2 |
| Sims 2, The: Apartment Pets | | | | 32 | none |
| Sims 2, The: Castaway | | | | 64 | 8.0 |
| Sims 2, The: Pets | | | | 32 | none |
| Sims 3, The | | | | 128 | 6.1 |
| Six Flags Fun Park | | | | 64 | none |
| Skate It | | | | 32 | 8.7 |
| Slingo Quest | | | | 8 | 5.5 |
| Smart Boy's Gameroom | | | | 16 | none |
| Smart Boy's Gameroom 2 | | | | 16 | none |
| Smart Boy's Toys Club | | | | 16 | none |
| Smart Boy's Winter Wonderland | | | | 16 | none |
| Smart Girl's Magical Book Club | | | | 64 | none |
| Smart Girl's Party Game | | | | 16 | none |
| Smart Girl's Playhouse | | | | 16 | none |
| Smart Girl's Playhouse 2 | | | | 16 | none |
| Smart Girl's Playhouse Party | | | | 64 | none |
| Smart Girl's Winter Wonderland | | | | 16 | none |
| Smart Kid's Gameclub | | | | 32 | none |
| Smart Kid's Mega Game Mix | | | | 32 | none |
| Smart Kid's Party Fun Pak | | | | 32 | none |
| SmileyWorld: Island Challenge | | | | 8 | none |
| Smurfs 2, The | | | | 32 | none |
| Smurfs, The | | | | 32 | none |
| SNK vs. Capcom: Card Fighters DS | | | | 32 | 7.0 |
| Snood 2: On Vacation | | | | 8 | none |
| Solatorobo: Red the Hunter | | | | 64 | 9.1 |
| Solitaire Overload | | | | 8 | none |
| Solitaire Overload Plus | | | | 8 | none |
| Sonic & Sega All-Stars Racing | | | | 64 | 6.9 |
| Sonic Chronicles: The Dark Brotherhood | | | | 128 | 7.3 |
| Sonic Classic Collection | | | | 64 | 8.1 |
| Sonic Colors | | | | 64 | 6.6 |
| Sonic Rush | | | | 64 | 8.8 |
| Sonic Rush Adventure | | | | 64 | 7.9 |
| Sonny with a Chance | | | | 64 | none |
| Sorcerer's Apprentice, The | | | | 64 | none |
| Soul Bubbles | | | | 32 | 7.0 |
| Space Bust-A-Move | | | | 32 | none |
| Space Camp | | | | 32 | none |
| Space Chimps | | | | 64 | none |
| Space Invaders Extreme | | | | 64 | 9.0 |
| Space Invaders Extreme 2 | | | | 64 | 8.8 |
| Space Invaders Revolution | | | | 16 | 6.0 |
| Spanish for Everyone! | | | | 32 | 2.0 |
| Spectral Force: Genesis | | | | 64 | 7.0 |
| Spectrobes | | | | 64 | 8.1 |
| Spectrobes: Beyond the Portals | | | | 128 | 9.0 |
| Speed Racer: The Videogame | | | | 64 | 8.0 |
| Spelling Challenges and More! | | | | 8 | none |
| Spider-Man 2 | | | | 16 | none |
| Spider-Man 3 | | | | 64 | none |
| Spider-Man: Battle for New York | | | | 64 | none |
| Spider-Man: Edge of Time | | | | 64 | 7.7 |
| Spider-Man: Friend or Foe | | | | 64 | 10.0 |
| Spider-Man: Shattered Dimensions | | | | 64 | 9.4 |
| Spider-Man: Web of Shadows | | | | 64 | 9.2 |
| Spiderwick Chronicles, The | | | | 64 | none |
| Spitfire Heroes: Tales of the Royal Air Force | | | | 16 | none |
| SpongeBob SquarePants featuring Nicktoons: Globs of Doom | | | | 32 | 7.5 |
| SpongeBob SquarePants: Creature from the Krusty Krab | | | | 32 | 8.5 |
| SpongeBob SquarePants: Plankton's Robotic Revenge | | | | 64 | 4.5 |
| SpongeBob SquarePants: The Yellow Avenger | | | | 32 | none |
| SpongeBob vs the Big One: Beach Party Cook-Off | | | | 64 | 7.0 |
| SpongeBob's Atlantis SquarePantis | | | | 32 | 8.3 |
| SpongeBob's Boating Bash | | | | 32 | 4.0 |
| SpongeBob's Truth or Square | | | | 32 | 8.0 |
| Spore Creatures | | | | 32 | 7.2 |
| Spore Hero Arena | | | | 64 | 7.0 |
| Sports Collection | | | | 32 | none |
| Sprung: A Game Where Everyone Scores | | | | 32 | 9.0 |
| Spy Kids: All the Time in the World | | | | 16 | 10.0 |
| Spyro: Shadow Legacy | | | | 64 | 5.8 |
| Squeeballs Party | | | | 32 | none |
| Squinkies 2: Adventure Mall Surprize! | | | | 32 | none |
| Squinkies: Surprize Inside | | | | 32 | none |
| Squishy Tank | | | | 16 | none |
| Star Fox Command | | | | 32 | 6.3 |
| Star Trek: Tactical Assault | | | | 16 | 7.0 |
| Star Wars: Battlefront - Elite Squadron | | | | 64 | 7.5 |
| Star Wars: Episode III - Revenge of the Sith | | | | 32 | 9.0 |
| Star Wars: Lethal Alliance | | | | 32 | none |
| Star Wars: The Clone Wars - Jedi Alliance | | | | 256 | 4.0 |
| Star Wars: The Clone Wars - Republic Heroes | | | | 128 | 9.0 |
| Star Wars: The Force Unleashed | | | | 64 | 9.0 |
| Star Wars: The Force Unleashed II | | | | 128 | 10.0 |
| Steal Princess | | | | 64 | 3.0 |
| Steel Horizon | | | | 32 | none |
| Stitch Jam | | | | 64 | none |
| Story of Noah's Ark, The | | | | 16 | none |
| Strawberry Shortcake: Strawberryland Games | | | | 16 | none |
| Strawberry Shortcake: The Four Seasons Cake | | | | 16 | none |
| Style Lab: Fashion Design | | | | 32 | none |
| Style Lab: Jewelry Design | | | | 32 | none |
| Style Lab: Makeover | | | | 32 | none |
| Style Savvy | | | | 128 | 9.4 |
| Sudoku Ball Detective | | | | 8 | none |
| Sudoku Gridmaster | | | | 8 | none |
| Sudoku Mania: Enhance Your Critical Thinking Skills! | | | | 8 | none |
| Sudokuro: Sudoku & Kakuro Games | | | | 8 | 1.0 |
| Suikoden: Tierkreis | | | | 256 | 9.2 |
| Suite Life of Zack & Cody, The: Circle of Spies | | | | 32 | none |
| Suite Life of Zack & Cody, The: Tipton Trouble | | | | 16 | none |
| Summon Night: Twin Age | | | | 128 | 10.0 |
| Super Black Bass Fishing | | | | 32 | none |
| Super Collapse! 3 | | | | 8 | none |
| Super Dodgeball Brawlers | | | | 8 | 8.5 |
| Super Fruit Fall | | | | 8 | none |
| Super Mario 64 DS | 2004 | | | 16 | 8.7 |
| Super Monkey Ball: Touch & Roll | | | | 64 | 8.0 |
| Super Princess Peach | | | | 32 | 9.0 |
| Super Robot Taisen OG Saga: Endless Frontier | | | | 128 | 8.7 |
| Super Scribblenauts | | | | 32 | 9.2 |
| Super Speed Machines | | | | 32 | none |
| Super Star Kartz | | | | 128 | none |
| Superman Returns | | | | 64 | none |
| Surf's Up | | | | 32 | none |
| Survivor | | | | 16 | none |
| Sushi Academy | | | | 16 | none |
| Sushi Go-Round | | | | 32 | none |
| Suzuki Super-Bikes II: Riding Challenge | | | | 16 | none |
