| Title | Region | Version | Year | Serial | Cart Size
(MB) | Rating |
| Safari Adventures: Africa |  | 1.0 | 2009 | NTR-CSAE-USA | 16 | 7.0 |
| Safecracker: The Ultimate Puzzle Challenge! | | 1.0 | 2009 | NTR-BSIE-USA | 64 | none |
| Sally's Salon | | 1.0 | 2008 | NTR-CSIE-USA | 16 | none |
| Salon Superstar | | 1.0 | 2009 | NTR-C39E-USA | 32 | none |
| Samantha Swift and the Hidden Roses of Athena | | 1.0 | 2010 | NTR-BHRE-USA | 32 | none |
| Sands of Destruction | | 1.0 | 2010 | NTR-YSLE-USA | 256 | 9.6 |
| Santa Claus is Comin' to Town | | 1.0 | 2011 | NTR-BX7E-USA | 16 | 7.8 |
| Sarah: Keeper of the Unicorn | | 1.0 | 2009 | NTR-YSAE-USA | 16 | 5.5 |
| Satisfashion: Rock the Runway | | 1.0 | 2010 | NTR-BS5E-USA | 16 | none |
| SBK: Snowboard Kids | | 1.0 | 2005 | NTR-ASBE-USA | 64 | 7.5 |
| Scene It Twilight | | 1.0 | 2010 | NTR-BT8E-USA | 128 | 5.5 |
| Science Papa | | 1.0 | 2009 | NTR-BSNE-USA | 32 | 7.0 |
| Scooby-Doo! and the Spooky Swamp | | 1.0 | 2010 | NTR-BJ2E-USA | 64 | 9.6 |
| Scooby-Doo!: First Frights | | 1.0 | 2009 | NTR-CQVE-USA | 64 | 7.0 |
| Scooby-Doo!: Unmasked | | 1.0 | 2005 | NTR-ASDE-USA | 16 | 5.5 |
| Scooby-Doo!: Who's Watching Who | | 1.0 | 2006 | NTR-AC6E-USA | 16 | 8.3 |
| Scrabble: Crossword Game | | 1.0 | 2009 | NTR-CVXE-USA | 64 | none |
| Scribblenauts | | 1.0 | 2009 | NTR-BSLE-USA | 32 | 9.3 |
| Scribblenauts Collection | | 1.0 | 2013 | NTR-TCSE-USA | 64 | 9.0 |
| Scripps Spelling Bee | | 1.0 | 2010 | TWL-VSPE-USA | 32 | none |
| Scurge: Hive | | 1.0 | 2006 | NTR-AHVE-USA | 16 | none |
| Sea Monsters: A Prehistoric Adventure | | 1.0 | 2008 | NTR-YS3E-USA | 8 | 10.0 |
| Sea Park Tycoon | | 1.0 | 2010 | NTR-C6TE-USA | 16 | none |
| Secret Files: Tunguska | | 1.0 | 2010 | NTR-YGSE-USA | 64 | 9.0 |
| Secret Saturdays, The: Beasts of the 5th Sun | | 1.0 | 2009 | NTR-BSYE-USA | 32 | none |
| SEGA Casino | | 1.0 | 2005 | NTR-ACAE-USA | 8 | none |
| SEGA Superstars Tennis | | 1.0 | 2008 | NTR-YT7E-USA | 64 | none |
| Sesame Street: Elmo's Musical Monsterpiece | | 1.0 | 2012 | NTR-B6LE-USA | 128 | none |
| Settlers, The | | 1.0 | 2007 | NTR-AUZE-USA | 64 | 10.0 |
| Shamu's Deep Sea Adventures | | 1.0 | 2005 | NTR-ABAE-USA | 32 | 5.5 |
| Shaun the Sheep | | 1.0 | 2008 | NTR-CSUE-USA | 32 | 8.3 |
| Shaun White Snowboarding | | 1.0 | 2008 | NTR-CU3E-USA | 32 | none |
| Shawn Johnson Gymnastics | | 1.0 | 2010 | NTR-BRVE-USA | 16 | none |
| Shepherd's Crossing 2 DS | | 1.0 | 2010 | NTR-BE2E-USA | 8 | 10.0 |
| Sherlock Holmes and the Mystery of Osborne House | | 1.0 | 2011 | NTR-B46E-USA | 16 | none |
| Sherlock Holmes: The Mystery of the Mummy | | 1.0 | 2009 | NTR-CS6E-USA | 64 | none |
| Shin Megami Tensei: Devil Survivor | | 1.0 | 2009 | NTR-CVIE-USA | 64 | 9.5 |
| Shin Megami Tensei: Devil Survivor 2 | | 1.0 | 2012 | NTR-TDVE-USA | 128 | 9.6 |
| Shin Megami Tensei: Strange Journey | | 1.0 | 2010 | NTR-BMTE-USA | 128 | 9.5 |
| Shining Stars: Super Starcade | | 1.0 | 2008 | NTR-CS2E-USA | 8 | none |
| Shorts | | 1.0 | 2009 | NTR-BSHE-USA | 32 | none |
| Showtime Championship Boxing | | 1.0 | 2007 | NTR-YSYE-USA | 16 | none |
| Shrek the Third | | 1.0 | 2007 | NTR-A3SE-USA | 32 | 8.7 |
| Shrek's Carnival Craze: Party Games | | 1.0 | 2008 | NTR-CLZE-USA | 64 | 8.5 |
| Shrek: Forever After | | 1.0 | 2010 | TWL-VSKE-USA | 64 | 8.9 |
| Shrek: Ogres & Dronkeys | | 1.0 | 2007 | NTR-YQ3E-USA | 64 | 6.6 |
| Shrek: Smash n' Crash Racing | | 1.0 | 2007 | NTR-A4IE-USA | 32 | 9.0 |
| Shrek: Super Slam | | 1.0 | 2005 | NTR-AS3E-USA | 32 | 8.3 |
| Sid Meier's Civilization Revolution | | 1.0 | 2008 | NTR-YS6E-USA | 64 | 8.0 |
| Sideswiped | | 1.0 | 2009 | NTR-BCLE-USA | 16 | 8.5 |
| Silly Bandz | | 1.0 | 2010 | NTR-BZEE-USA | 8 | 10.0 |
| Silverlicious | | 1.0 | 2012 | NTR-TASE-USA | 16 | 10.0 |
| SimAnimals | | 1.0 | 2009 | NTR-CM3E-USA | 128 | none |
| SimAnimals: Africa | | 1.0 | 2009 | NTR-C27E-USA | 128 | 8.0 |
| SimCity DS | | 1.0 | 2007 | NTR-AC3E-USA | 64 | 7.8 |
| SimCity: Creator | | 1.0 | 2008 | NTR-YC2E-USA | 64 | 9.0 |
| Simpsons Game, The | | 1.0 | 2007 | NTR-YSZE-USA | 128 | 8.8 |
| Sims 2, The | | 1.0 | 2005 | NTR-ASJE-USA | 64 | 7.5 |
| Sims 2, The: Apartment Pets | | 1.0 | 2008 | NTR-CAPE-USA | 32 | none |
| Sims 2, The: Castaway | | 1.0 | 2007 | NTR-YS2E-USA | 64 | 8.0 |
| Sims 2, The: Pets | | 1.0 | 2006 | NTR-A4OE-USA | 32 | none |
| Sims 3, The | | 1.0 | 2010 | TWL-VS3E-USA | 128 | 5.9 |
| Six Flags Fun Park | | 1.0 | 2008 | NTR-CF6E-USA | 64 | none |
| Skate It | | 1.0 | 2008 | NTR-CSVE-USA | 32 | 8.7 |
| Slingo Quest | | 1.0 | 2008 | NTR-CSLE-USA | 8 | 5.5 |
| Smart Boy's Gameroom | | 1.0 | 2007 | NTR-A2HE-USA | 16 | none |
| Smart Boy's Gameroom 2 | | 1.0 | 2009 | NTR-BS3E-USA | 16 | none |
| Smart Boy's Toys Club | | 1.0 | 2008 | NTR-CSXE-USA | 16 | none |
| Smart Boy's Winter Wonderland | | 1.0 | 2008 | NTR-YITE-USA | 16 | none |
| Smart Girl's Magical Book Club | | 1.0 | 2008 | NTR-YI8E-USA | 64 | none |
| Smart Girl's Party Game | | 1.0 | 2008 | NTR-CSYE-USA | 16 | none |
| Smart Girl's Playhouse | | 1.0 | 2007 | NTR-A2IE-USA | 16 | none |
| Smart Girl's Playhouse 2 | | 1.0 | 2009 | NTR-BS4E-USA | 16 | none |
| Smart Girl's Playhouse Party | | 1.0 | 2010 | NTR-BG7E-USA | 64 | none |
| Smart Girl's Winter Wonderland | | 1.0 | 2008 | NTR-CWIE-USA | 16 | none |
| Smart Kid's Gameclub | | 1.0 | 2007 | NTR-YIDE-USA | 32 | none |
| Smart Kid's Mega Game Mix | | 1.0 | 2009 | NTR-BS2E-USA | 32 | none |
| Smart Kid's Party Fun Pak | | 1.0 | 2008 | NTR-CSZE-USA | 32 | 1.0 |
| SmileyWorld: Island Challenge | | 1.0 | 2009 | NTR-CWJE-USA | 8 | none |
| Smurfs 2, The | | 1.0 | 2013 | NTR-TR2E-USA | 32 | none |
| Smurfs, The | | 1.0 | 2011 | NTR-BZUE-USA | 32 | none |
| SNK vs. Capcom: Card Fighters DS | | 1.1 | 2007 | NTR-AVSE-USA | 32 | 7.0 |
| Snood 2: On Vacation | | 1.0 | 2005 | NTR-ASVE-USA | 8 | 10.0 |
| Solatorobo: Red the Hunter | | 1.0 | | TWL-VCDE-USA | 64 | 9.2 |
| Solitaire Overload | | 1.0 | | NTR-YOVE-USA | 8 | none |
| Solitaire Overload Plus | | 1.0 | | NTR-B7LE-USA | 8 | none |
| Sonic & SEGA All-Stars Racing | | 1.0 | | NTR-CS3E-USA | 64 | 7.4 |
| Sonic Chronicles: The Dark Brotherhood | | 1.0 | | NTR-YWSE-USA | 128 | 7.2 |
| Sonic Classic Collection | | 1.0 | | TWL-VSOE-USA | 64 | 8.2 |
| Sonic Colors | | 1.0 | | NTR-BXSE-USA | 64 | 7.5 |
| Sonic Rush | | 1.0 | | NTR-ASCE-USA | 64 | 8.7 |
| Sonic Rush Adventure | | 1.0 | | NTR-A3YE-USA | 64 | 8.3 |
| Sonny with a Chance | | 1.0 | | TWL-VSNE-USA | 64 | none |
| Sorcerer's Apprentice, The | | 1.0 | | NTR-BS8E-USA | 64 | none |
| Soul Bubbles | | 1.0 | | NTR-YLEE-USA | 32 | 7.0 |
| Space Bust-A-Move | | 1.0 | | NTR-CB6E-USA | 32 | none |
| Space Camp | | 1.0 | | NTR-C5AE-USA | 32 | none |
| Space Chimps | | 1.0 | | NTR-CMPE-USA | 64 | none |
| Space Invaders Extreme | | 1.0 | | NTR-YXXE-USA | 64 | 9.0 |
| Space Invaders Extreme 2 | | 1.0 | | NTR-CV8E-USA | 64 | 8.8 |
| Space Invaders Revolution | | 1.0 | | NTR-AISE-USA | 16 | 6.0 |
| Spanish for Everyone! | | 1.0 | | NTR-YSHE-USA | 32 | 2.0 |
| Spectral Force: Genesis | | 1.0 | | NTR-YW4E-USA | 64 | 7.0 |
| Spectrobes | | 1.0 | | NTR-ASUE-USA | 64 | 8.1 |
| Spectrobes: Beyond the Portals | | 1.0 | | NTR-YV4E-USA | 128 | 9.0 |
| Speed Racer: The Videogame | | 1.0 | | NTR-YYRE-USA | 64 | 8.0 |
| Spelling Challenges and More! | | 1.0 | | NTR-AQ5E-USA | 8 | none |
| Spider-Man 2 | | 1.0 | | NTR-AS2E-USA | 16 | none |
| Spider-Man 3 | | 1.0 | | NTR-AQ3E-USA | 64 | none |
| Spider-Man: Battle for New York | | 1.0 | | NTR-AC9E-USA | 64 | none |
| Spider-Man: Edge of Time | | 1.0 | | NTR-B8IE-USA | 64 | 7.7 |
| Spider-Man: Friend or Foe | | 1.0 | | NTR-YSFE-USA | 64 | 10.0 |
| Spider-Man: Shattered Dimensions | | 1.0 | | NTR-B3PE-USA | 64 | 9.4 |
| Spider-Man: Web of Shadows | | 1.0 | | NTR-CS5E-USA | 64 | 9.0 |
| Spiderwick Chronicles, The | | 1.0 | | NTR-YS8E-USA | 64 | none |
| Spitfire Heroes: Tales of the Royal Air Force | | 1.0 | | NTR-YRAE-USA | 16 | none |
| SpongeBob SquarePants Featuring Nicktoons: Globs of Doom | | 1.0 | | NTR-CS9E-USA | 32 | 7.5 |
| SpongeBob SquarePants: Creature from the Krusty Krab | | 1.0 | | NTR-AQ4E-USA | 32 | 6.0 |
| SpongeBob SquarePants: Plankton's Robotic Revenge | | 1.0 | | NTR-TLUE-USA | 64 | 4.5 |
| SpongeBob SquarePants: The Yellow Avenger | | 1.0 | | NTR-AS9E-USA | 32 | 6.3 |
| SpongeBob vs the Big One: Beach Party Cook-Off | | 1.0 | | NTR-CCKE-USA | 64 | 7.0 |
| SpongeBob's Atlantis SquarePantis | | 1.0 | | NTR-AL3E-USA | 32 | 9.2 |
| SpongeBob's Boating Bash | | 1.0 | | TWL-VBVE-USA | 32 | 7.0 |
| SpongeBob's Truth or Square | | 1.0 | | NTR-BSOE-USA | 32 | 8.0 |
| Spore Creatures | | 1.0 | | NTR-YSPE-USA | 32 | 7.9 |
| Spore Hero Arena | | 1.0 | | NTR-C49E-USA | 64 | 7.0 |
| Sports Collection | | 1.0 | | NTR-B2UE-USA | 32 | none |
| Sprung: A Game Where Everyone Scores | | 1.0 | | NTR-ACRE-USA | 32 | 9.0 |
| Spy Kids: All the Time in the World | | 1.0 | | NTR-B7YE-USA | 16 | 5.5 |
| Spyro: Shadow Legacy | | 1.0 | | NTR-ASSE-USA | 64 | 5.8 |
| Squeeballs Party | | 1.0 | | NTR-BSVE-USA | 32 | none |
| Squinkies 2: Adventure Mall Surprize! | | 1.0 | | NTR-BZJE-USA | 32 | none |
| Squinkies: Surprise Inside | | 1.1 | | NTR-BXQE-USA | | none |
| Squinkies: Surprize Inside | | 1.0 | | NTR-BXQE-USA | 32 | none |
| Squishy Tank | | 1.0 | | NTR-CYWE-USA | 16 | none |
| Star Fox Command |  | 1.0 | | NTR-ASFE-USA | 32 | 6.6 |
| Star Trek: Tactical Assault | | 1.0 | | NTR-ATJE-USA | 16 | 7.0 |
| Star Wars: Battlefront - Elite Squadron | | 1.0 | | NTR-CSWE-USA | 64 | 7.5 |
| Star Wars: Episode III - Revenge of the Sith | | 1.0 | | NTR-ASTE-USA | 32 | 9.0 |
| Star Wars: Lethal Alliance | | 1.0 | | NTR-AWUE-USA | 32 | none |
| Star Wars: The Clone Wars - Jedi Alliance | | 1.0 | | NTR-CLWE-USA | 256 | 4.0 |
| Star Wars: The Clone Wars - Republic Heroes | | 1.0 | | NTR-BW9E-USA | 128 | 9.0 |
| Star Wars: The Force Unleashed | | 1.0 | | NTR-YSTE-USA | 64 | 9.0 |
| Star Wars: The Force Unleashed II | | 1.0 | | NTR-B2SE-USA | 128 | 7.0 |
| Steal Princess | | 1.0 | | NTR-YP9E-USA | 64 | 3.0 |
| Steel Horizon | | 1.0 | | NTR-AS4E-USA | 32 | none |
| Stitch Jam | | 1.0 | | NTR-BJME-USA | 64 | 9.0 |
| Story of Noah's Ark, The | | 1.0 | | NTR-BXNE-USA | 16 | 7.0 |
| Strawberry Shortcake: Strawberryland Games | | 1.0 | | NTR-AS5E-USA | 16 | none |
| Strawberry Shortcake: The Four Seasons Cake | | 1.0 | | NTR-YSXE-USA | 16 | none |
| Style Lab: Fashion Design | | 1.0 | | NTR-BYLE-USA | 32 | none |
| Style Lab: Jewelry Design | | 1.1 | | TWL-VJWE-USA | 32 | none |
| Style Lab: Makeover | | 1.0 | | TWL-VMOE-USA | 32 | none |
| Style Savvy | | 1.0 | | NTR-AZLE-USA | 128 | 9.4 |
| Sudoku Ball Detective | | 1.0 | | NTR-C3BE-USA | 8 | none |
| Sudoku Gridmaster | | 1.0 | | NTR-ASQE-USA | 8 | none |
| Sudoku Mania: Enhance Your Critical Thinking Skills! | | 1.0 | | NTR-AQME-USA | 8 | none |
| Sudokuro: Sudoku & Kakuro Games | | 1.0 | | NTR-AX2E-USA | 8 | 1.0 |
| Suikoden: Tierkreis | | 1.0 | | NTR-YG4E-USA | 256 | 9.3 |
| Suite Life of Zack & Cody, The: Circle of Spies | | 1.0 | | NTR-A3HE-USA | 32 | none |
| Suite Life of Zack & Cody, The: Tipton Trouble | | 1.0 | | NTR-ASLE-USA | 16 | none |
| Summon Night: Twin Age | | 1.0 | | NTR-AS7E-USA | 128 | 10.0 |
| Super Black Bass Fishing | | 1.0 | | NTR-AB8E-USA | 32 | none |
| Super Collapse! 3 | | 1.0 | | NTR-AULE-USA | 8 | none |
| Super Dodgeball Brawlers | | 1.0 | | NTR-YDVE-USA | 8 | 8.5 |
| Super Fruit Fall | | 1.0 | | NTR-AFTE-USA | 8 | none |
| Super Mario 64 DS | | 1.1 | 2004 | NTR-ASME-USA | 16 | 8.6 |
| Super Monkey Ball: Touch & Roll | | 1.0 | | NTR-AMOE-USA | 64 | 8.3 |
| Super Princess Peach | | 1.0 | | NTR-ASPE-USA | 32 | 9.0 |
| Super Robot Taisen OG Saga: Endless Frontier | | 1.0 | | NTR-CFRE-USA | 128 | 8.7 |
| Super Scribblenauts | | 1.0 | | NTR-BH2E-USA | 32 | 9.2 |
| Super Speed Machines | | 1.0 | | NTR-BG6E-USA | 32 | 7.0 |
| Super Star Kartz | | 1.0 | | NTR-BZAE-USA | 128 | none |
| Superman Returns | | 1.0 | | NTR-ARPE-USA | 64 | 3.0 |
| Surf's Up | | 1.1 | | NTR-AXUE-USA | 32 | none |
| Survivor | | 1.0 | | NTR-YL8E-USA | 16 | none |
| Sushi Academy | | 1.0 | | NTR-CSDE-USA | 16 | none |
| Sushi Go-Round | | 1.0 | | TWL-VSGE-USA | 32 | none |
| Suzuki Super-Bikes II: Riding Challenge | | 1.0 | | NTR-AVBE-USA | 16 | none |
