| Safari Adventures: Africa | 16 | none |
| Safecracker: The Ultimate Puzzle Challenge! | 64 | none |
| Sally's Salon | 16 | none |
| Salon Superstar | 32 | none |
| Samantha Swift and the Hidden Roses of Athena | 32 | none |
| Sands of Destruction | 256 | 10.0 |
| Santa Claus is Comin' to Town | 16 | none |
| Sarah: Keeper of the Unicorn | 16 | 10.0 |
| Satisfashion: Rock the Runway | 16 | none |
| SBK: Snowboard Kids | 64 | none |
| Scene It Twilight | 128 | none |
| Science Papa | 32 | none |
| Scooby-Doo! and the Spooky Swamp | 64 | none |
| Scooby-Doo! First Frights | 64 | none |
| Scooby-Doo! Unmasked | 16 | none |
| Scooby-Doo! Who's Watching Who | 16 | none |
| Scrabble: Crossword Game | 64 | none |
| Scribblenauts | 32 | none |
| Scribblenauts Collection | 64 | 9.0 |
| Scripps Spelling Bee | 32 | none |
| Scurge: Hive | 16 | none |
| Sea Monsters: A Prehistoric Adventure | 8 | 10.0 |
| Sea Park Tycoon | 16 | none |
| Secret Files: Tunguska | 64 | none |
| Secret Saturdays, The: Beasts of the 5th Sun | 32 | none |
| Sega Casino | 8 | none |
| Sega Superstars Tennis | 64 | none |
| Sesame Street: Elmo's Musical Monsterpiece | 128 | none |
| Settlers, The | 64 | 10.0 |
| Shamu's Deep Sea Adventures | 32 | none |
| Shaun the Sheep | 32 | none |
| Shaun White Snowboarding | 32 | none |
| Shawn Johnson Gymnastics | 16 | none |
| Shepherd's Crossing 2 DS | 8 | none |
| Sherlock Holmes and the Mystery of Osborne House | 16 | none |
| Sherlock Holmes: The Mystery of the Mummy | 64 | none |
| Shin Megami Tensei: Devil Survivor | 64 | 8.7 |
| Shin Megami Tensei: Devil Survivor 2 | 128 | 9.0 |
| Shin Megami Tensei: Strange Journey | 128 | 9.0 |
| Shining Stars: Super Starcade | 8 | none |
| Shorts | 32 | none |
| Showtime Championship Boxing | 16 | none |
| Shrek the Third | 32 | 3.0 |
| Shrek's Carnival Craze: Party Games | 64 | 10.0 |
| Shrek: Forever After | 64 | 10.0 |
| Shrek: Ogres & Dronkeys | 64 | 10.0 |
| Shrek: Smash n' Crash Racing | 32 | 10.0 |
| Shrek: Super Slam | 32 | 10.0 |
| Sid Meier's Civilization Revolution | 64 | 8.0 |
| Sideswiped | 16 | 7.0 |
| Sillybandz DS | 8 | none |
| Silverlicious | 16 | 10.0 |
| SimAnimals | 128 | none |
| SimAnimals: Africa | 128 | 8.0 |
| SimCity DS | 64 | 7.3 |
| SimCity: Creator | 64 | 8.5 |
| Simpsons Game, The | 128 | 10.0 |
| Sims 2, The | 64 | 7.0 |
| Sims 2, The: Apartment Pets | 32 | none |
| Sims 2, The: Castaway | 64 | none |
| Sims 2, The: Pets | 32 | none |
| Sims 3, The | 128 | 4.0 |
| Six Flags Fun Park | 64 | none |
| Skate It | 32 | 7.0 |
| Slingo Quest | 8 | none |
| Smart Boy's Gameroom | 16 | none |
| Smart Boy's Gameroom 2 | 16 | none |
| Smart Boy's Toys Club | 16 | none |
| Smart Boy's Winter Wonderland | 16 | none |
| Smart Girl's Magical Book Club | 64 | none |
| Smart Girl's Party Game | 16 | none |
| Smart Girl's Playhouse | 16 | none |
| Smart Girl's Playhouse 2 | 16 | none |
| Smart Girl's Playhouse Party | 64 | none |
| Smart Girl's Winter Wonderland | 16 | none |
| Smart Kid's Gameclub | 32 | none |
| Smart Kid's Mega Game Mix | 32 | none |
| Smart Kid's Party Fun Pak | 32 | none |
| SmileyWorld: Island Challenge | 8 | none |
| Smurfs 2, The | 32 | none |
| Smurfs, The | 32 | none |
| SNK vs. Capcom: Card Fighters DS | 32 | 7.0 |
| Snood 2: On Vacation | 8 | none |
| Solatorobo: Red the Hunter | 64 | 9.0 |
| Solitaire Overload | 8 | none |
| Solitaire Overload Plus | 8 | none |
| Sonic & Sega All-Stars Racing | 64 | 9.0 |
| Sonic Chronicles: The Dark Brotherhood | 128 | 7.6 |
| Sonic Classic Collection | 64 | 8.6 |
| Sonic Colors | 64 | 9.3 |
| Sonic Rush | 64 | 9.1 |
| Sonic Rush Adventure | 64 | 9.6 |
| Sonny with a Chance | 64 | none |
| Sorcerer's Apprentice, The | 64 | none |
| Soul Bubbles | 32 | none |
| Space Bust-A-Move | 32 | none |
| Space Camp | 32 | none |
| Space Chimps | 64 | none |
| Space Invaders Extreme | 64 | 9.0 |
| Space Invaders Extreme 2 | 64 | 8.0 |
| Space Invaders Revolution | 16 | 2.0 |
| Spanish for Everyone! | 32 | none |
| Spectral Force: Genesis | 64 | none |
| Spectrobes | 64 | 7.7 |
| Spectrobes: Beyond the Portals | 128 | 9.0 |
| Speed Racer: The Videogame | 64 | 7.0 |
| Spelling Challenges and More! | 8 | none |
| Spider-Man 2 | 16 | none |
| Spider-Man 3 | 64 | none |
| Spider-Man: Battle for New York | 64 | none |
| Spider-Man: Edge of Time | 64 | 6.0 |
| Spider-Man: Friend or Foe | 64 | none |
| Spider-Man: Shattered Dimensions | 64 | none |
| Spider-Man: Web of Shadows | 64 | 8.5 |
| Spiderwick Chronicles, The | 64 | none |
| Spitfire Heroes: Tales of the Royal Air Force | 16 | none |
| SpongeBob SquarePants featuring Nicktoons: Globs of Doom | 32 | 5.0 |
| SpongeBob SquarePants: Creature from the Krusty Krab | 32 | 7.0 |
| SpongeBob SquarePants: Plankton's Robotic Revenge | 64 | none |
| SpongeBob SquarePants: The Yellow Avenger | 32 | none |
| SpongeBob vs the Big One: Beach Party Cook-Off | 64 | none |
| SpongeBob's Atlantis SquarePantis | 32 | 8.0 |
| SpongeBob's Boating Bash | 32 | none |
| SpongeBob's Truth or Square | 32 | 7.0 |
| Spore Creatures | 32 | 6.5 |
| Spore Hero Arena | 64 | none |
| Sports Collection | 32 | none |
| Sprung: A Game Where Everyone Scores | 32 | none |
| Spy Kids: All the Time in the World | 16 | 10.0 |
| Spyro: Shadow Legacy | 64 | none |
| Squeeballs Party | 32 | none |
| Squinkies 2: Adventure Mall Surprize! | 32 | none |
| Squinkies: Surprise Inside | 32 | none |
| Squinkies: Surprize Inside | 32 | none |
| Squishy Tank | 16 | none |
| Star Fox Command | 32 | 7.0 |
| Star Trek: Tactical Assault | 16 | none |
| Star Wars: Battlefront - Elite Squadron | 64 | none |
| Star Wars: Episode III - Revenge of the Sith | 32 | 10.0 |
| Star Wars: Lethal Alliance | 32 | none |
| Star Wars: The Clone Wars - Jedi Alliance | 256 | none |
| Star Wars: The Clone Wars - Republic Heroes | 128 | none |
| Star Wars: The Force Unleashed | 64 | 8.5 |
| Star Wars: The Force Unleashed II | 128 | none |
| Steal Princess | 64 | 3.0 |
| Steel Horizon | 32 | none |
| Stitch Jam | 64 | none |
| Story of Noah's Ark, The | 16 | none |
| Strawberry Shortcake: Strawberryland Games | 16 | none |
| Strawberry Shortcake: The Four Seasons Cake | 16 | none |
| Style Lab: Fashion Design | 32 | none |
| Style Lab: Jewelry Design | 32 | none |
| Style Lab: Makeover | 32 | none |
| Style Savvy | 128 | 9.8 |
| Sudoku Ball Detective | 8 | none |
| Sudoku Gridmaster | 8 | none |
| Sudoku Mania: Enhance Your Critical Thinking Skills! | 8 | none |
| Sudokuro: Sudoku & Kakuro Games | 8 | 1.0 |
| Suikoden: Tierkreis | 256 | none |
| Suite Life of Zack & Cody, The: Circle of Spies | 32 | none |
| Suite Life of Zack & Cody, The: Tipton Trouble | 16 | none |
| Summon Night: Twin Age | 128 | none |
| Super Black Bass Fishing | 32 | none |
| Super Collapse! 3 | 8 | none |
| Super Dodgeball Brawlers | 8 | 10.0 |
| Super Fruit Fall | 8 | none |
| Super Mario 64 DS | 16 | 8.1 |
| Super Monkey Ball: Touch & Roll | 64 | 7.8 |
| Super Princess Peach | 32 | 9.4 |
| Super Robot Taisen OG Saga: Endless Frontier | 128 | 8.0 |
| Super Scribblenauts | 32 | 8.0 |
| Super Speed Machines | 32 | none |
| Super Star Kartz | 128 | none |
| Superman Returns | 64 | none |
| Surf's Up | 32 | none |
| Survivor | 16 | none |
| Sushi Academy | 16 | none |
| Sushi Go-Round | 32 | none |
| Suzuki Super-Bikes II: Riding Challenge | 16 | none |
