| Title | Region | Version | Languages | Rating |
| Safari Adventures: Africa |  | 1.00 | - | 7.0 |
| Safecracker: The Ultimate Puzzle Challenge! | | 1.00 | en es fr | 10.0 |
| Sally's Salon | | 1.00 | - | 9.3 |
| Salon Superstar | | 1.00 | de en es fr it | 10.0 |
| Samantha Swift and the Hidden Roses of Athena | | 1.00 | - | none |
| Sands of Destruction | | 1.00 | - | 9.5 |
| Santa Claus is Comin' to Town | | 1.00 | - | 8.2 |
| Sarah: Keeper of the Unicorn | | 1.00 | en es | 5.5 |
| Satisfashion: Rock the Runway | | 1.00 | - | none |
| SBK: Snowboard Kids | | 1.00 | - | 7.5 |
| Scene It Twilight | | 1.00 | en es fr | 5.5 |
| Science Papa | | 1.00 | en fr | 6.3 |
| Scooby-Doo! and the Spooky Swamp | | 1.00 | en es fr | 9.6 |
| Scooby-Doo! First Frights | | 1.00 | de en es fr it | 7.3 |
| Scooby-Doo! Unmasked | | 1.00 | en fr | 7.0 |
| Scooby-Doo! Who's Watching Who | | 1.00 | - | 8.3 |
| Scrabble: Crossword Game | | 1.00 | - | none |
| Scribblenauts | | 1.00 | en es fr pt | 9.4 |
| Scribblenauts Collection | | 1.00 | - | 9.3 |
| Scripps Spelling Bee | | 1.00 | - | none |
| Scurge: Hive | | 1.00 | en es fr | 8.0 |
| Sea Monsters: A Prehistoric Adventure | | 1.00 | - | 7.5 |
| Sea Park Tycoon | | 1.00 | - | 10.0 |
| Secret Files: Tunguska | | 1.00 | de en es fr it | 9.0 |
| Secret Saturdays, The: Beasts of the 5th Sun | | 1.00 | en es fr | 6.0 |
| SEGA Casino | | 1.00 | de en es fr it | 7.7 |
| SEGA Superstars Tennis | | 1.00 | de en es fr it | 8.6 |
| Sesame Street: Elmo's Musical Monsterpiece | | 1.00 | en es | 10.0 |
| Settlers, The | | 1.00 | de en es fr it | 8.5 |
| Shamu's Deep Sea Adventures | | 1.00 | - | 5.5 |
| Shaun the Sheep | | 1.00 | de en es fr it ja | 8.3 |
| Shaun White Snowboarding | | 1.00 | en es fr | 10.0 |
| Shawn Johnson Gymnastics | | 1.00 | en es fr | none |
| Shepherd's Crossing 2 DS | | 1.00 | - | 8.7 |
| Sherlock Holmes and the Mystery of Osborne House | | 1.00 | en es fr | none |
| Sherlock Holmes: The Mystery of the Mummy | | 1.00 | en es fr | none |
| Shin Megami Tensei: Devil Survivor | | 1.00 | - | 9.1 |
| Shin Megami Tensei: Devil Survivor 2 | | 1.00 | - | 8.5 |
Shin Megami Tensei: Strange Journey  | | 1.00 | - | 8.3 |
| Shining Stars: Super Starcade | | 1.00 | - | none |
| Shorts | | 1.00 | en fr | none |
| Showtime Championship Boxing | | 1.00 | - | none |
| Shrek the Third | | 1.00 | - | 8.7 |
| Shrek's Carnival Craze: Party Games | | 1.00 | en fr | 8.7 |
| Shrek: Forever After | | 1.00 | en fr | 9.0 |
| Shrek: Ogres & Dronkeys | | 1.00 | - | 5.7 |
| Shrek: Smash n' Crash Racing | | 1.00 | - | 8.8 |
| Shrek: Super Slam | | 1.00 | - | 8.6 |
| Sid Meier's Civilization Revolution | | 1.00 | de en es fr it | 7.4 |
| Sideswiped | | 1.00 | - | 9.0 |
| Silly Bandz | | 1.00 | en es fr | 8.2 |
| Silverlicious | | 1.00 | - | 10.0 |
| SimAnimals | | 1.00 | da de en es fr it nl no pt sv | 7.7 |
| SimAnimals: Africa | | 1.00 | de en fr ja nl pt | 8.5 |
| SimCity DS | | 1.00 | de en es fr it nl | 7.8 |
| SimCity: Creator | | 1.00 | en es fr | 8.8 |
| Simpsons Game, The | | 1.00 | - | 8.5 |
| Sims 2, The | | 1.00 | de en es fr it | 8.1 |
| Sims 2, The: Apartment Pets | | 1.00 | de en es fr it nl | 10.0 |
| Sims 2, The: Castaway | | 1.00 | de en es fr it nl pt | 8.8 |
| Sims 2, The: Pets | | 1.00 | de en es fr it nl | 4.0 |
| Sims 3, The | | 1.00 | en es fr | 6.4 |
| Six Flags Fun Park | | 1.00 | en fr | none |
| Skate It | | 1.00 | de en es fr it nl | 9.0 |
| Slingo Quest | | 1.00 | - | 5.5 |
| Smart Boy's Gameroom | | 1.00 | - | none |
| Smart Boy's Gameroom 2 | | 1.00 | - | none |
| Smart Boy's Toys Club | | 1.00 | - | none |
| Smart Boy's Winter Wonderland | | 1.00 | - | none |
| Smart Girl's Magical Book Club | | 1.00 | - | none |
| Smart Girl's Party Game | | 1.00 | - | none |
| Smart Girl's Playhouse | | 1.00 | - | none |
| Smart Girl's Playhouse 2 | | 1.00 | - | none |
| Smart Girl's Playhouse Party | | 1.00 | - | none |
| Smart Girl's Winter Wonderland | | 1.00 | - | none |
| Smart Kid's Gameclub | | 1.00 | - | none |
| Smart Kid's Mega Game Mix | | 1.00 | - | none |
| Smart Kid's Party Fun Pak | | 1.00 | - | 5.5 |
| SmileyWorld: Island Challenge | | 1.00 | en es fr | none |
| Smurfs 2, The | | 1.00 | en es fr | 8.0 |
| Smurfs, The | | 1.00 | en fr | none |
| SNK vs. Capcom: Card Fighters DS | | 1.10 | - | 8.3 |
| Snood 2: On Vacation | | 1.00 | - | 8.3 |
| Solatorobo: Red the Hunter | | 1.00 | de en es fr it | 8.1 |
| Solitaire Overload | | 1.00 | - | none |
| Solitaire Overload Plus | | 1.00 | en es fr | none |
| Sonic & SEGA All-Stars Racing | | 1.00 | en es fr | 8.2 |
| Sonic Chronicles: The Dark Brotherhood | | 1.00 | de en es fr it | 6.9 |
| Sonic Classic Collection | | 1.00 | en es fr | 8.0 |
| Sonic Colors | | 1.00 | de en es fr it ja | 7.6 |
| Sonic Rush | | 1.00 | de en es fr it ja | 8.1 |
| Sonic Rush Adventure | | 1.00 | de en es fr it ja | 7.8 |
| Sonny with a Chance | | 1.00 | en es fr | 6.0 |
| Sorcerer's Apprentice, The | | 1.00 | en es | none |
| Soul Bubbles | | 1.00 | de en es fr it | 7.0 |
| Space Bust-A-Move | | 1.00 | de en es fr it | 9.0 |
| Space Camp | | 1.00 | en fr | 2.0 |
| Space Chimps | | 1.00 | en fr | none |
| Space Invaders Extreme | | 1.00 | de en es fr it ja | 9.0 |
| Space Invaders Extreme 2 | | 1.00 | de en es fr it ja | 9.0 |
| Space Invaders Revolution | | 1.00 | de en es fr it | 6.0 |
| Spanish for Everyone! | | 1.00 | - | 5.6 |
| Spectral Force: Genesis | | 1.00 | - | 7.0 |
| Spectrobes | | 1.00 | de en es fr it | 8.3 |
| Spectrobes: Beyond the Portals | | 1.00 | - | 8.7 |
| Speed Racer: The Videogame | | 1.00 | en es fr pt | 8.8 |
| Spelling Challenges and More! | | 1.00 | - | none |
| Spider-Man 2 | | 1.00 | - | 8.0 |
| Spider-Man 3 | | 1.00 | - | 8.0 |
| Spider-Man: Battle for New York | | 1.00 | - | 8.5 |
| Spider-Man: Edge of Time | | 1.00 | en fr | 7.3 |
| Spider-Man: Friend or Foe | | 1.00 | - | 8.2 |
| Spider-Man: Shattered Dimensions | | 1.00 | en fr | 8.3 |
| Spider-Man: Web of Shadows | | 1.00 | en fr | 8.3 |
| Spiderwick Chronicles, The | | 1.00 | de en es fr it | 10.0 |
| Spitfire Heroes: Tales of the Royal Air Force | | 1.00 | - | 10.0 |
| SpongeBob SquarePants Featuring Nicktoons: Globs of Doom | | 1.00 | en fr | 8.4 |
| SpongeBob SquarePants: Creature from the Krusty Krab | | 1.00 | - | 7.0 |
| SpongeBob SquarePants: Plankton's Robotic Revenge | | 1.00 | en fr | 5.8 |
| SpongeBob SquarePants: The Yellow Avenger | | 1.00 | - | 5.5 |
| SpongeBob vs the Big One: Beach Party Cook-Off | | 1.00 | en fr | 7.2 |
| SpongeBob's Atlantis SquarePantis | | 1.00 | - | 9.1 |
| SpongeBob's Boating Bash | | 1.00 | - | 5.2 |
| SpongeBob's Surf & Skate: Roadtrip | | 1.00 | en es fr | 5.3 |
| SpongeBob's Truth or Square | | 1.00 | - | 8.5 |
| Spore Creatures | | 1.00 | de en es fr it nl | 8.2 |
| Spore Hero Arena | | 1.00 | de en es fr it nl | 8.5 |
| Sports Collection | | 1.00 | en fr | none |
| Sprung: A Game Where Everyone Scores | | 1.00 | - | 8.0 |
| Spy Kids: All the Time in the World | | 1.00 | - | 6.5 |
| Spyro: Shadow Legacy | | 1.00 | - | 6.5 |
| Squeeballs Party | | 1.00 | - | none |
| Squinkies 2: Adventure Mall Surprize! | | 1.00 | en fr | none |
| Squinkies: Surprise Inside | | 1.10 | en fr | none |
| Squinkies: Surprize Inside | | 1.00 | - | none |
| Squishy Tank | | 1.00 | - | 8.5 |
| Star Fox Command |  | 1.00 | - | 9.0 |
| Star Fox Command (Wii U Virtual Console) | | 1.00 | - | none |
| Star Trek: Tactical Assault | | 1.00 | - | 7.5 |
| Star Wars: Battlefront - Elite Squadron | | 1.00 | en fr | 7.7 |
| Star Wars: Episode III - Revenge of the Sith | | 1.00 | de en es fr it nl | 9.2 |
| Star Wars: Lethal Alliance | | 1.00 | de en es fr it | none |
| Star Wars: The Clone Wars - Jedi Alliance | | 1.00 | de en es fr | 5.0 |
| Star Wars: The Clone Wars - Republic Heroes | | 1.00 | de en es fr it | 8.3 |
| Star Wars: The Force Unleashed | | 1.00 | de en es fr it | 9.0 |
| Star Wars: The Force Unleashed II | | 1.00 | de en es fr it | 7.6 |
| Steal Princess | | 1.00 | - | 7.7 |
| Steel Horizon | | 1.00 | - | none |
| Stitch Jam | | 1.00 | - | 8.5 |
| Story of Noah's Ark, The | | 1.00 | - | 7.0 |
| Strawberry Shortcake: Strawberryland Games | | 1.00 | en es fr | none |
| Strawberry Shortcake: The Four Seasons Cake | | 1.00 | en es fr | 8.0 |
| Style Lab: Fashion Design | | 1.00 | en es fr | none |
| Style Lab: Jewelry Design | | 1.10 | en es fr | none |
| Style Lab: Makeover | | 1.00 | en es fr | none |
| Style Savvy | | 1.00 | - | 9.4 |
| Style Savvy (Wii U Virtual Console) | | 1.00 | - | none |
| Sudoku Ball Detective | | 1.00 | en es fr | none |
| Sudoku Gridmaster | | 1.00 | - | 10.0 |
| Sudoku Mania: Enhance Your Critical Thinking Skills! | | 1.00 | - | none |
| Sudokuro: Sudoku & Kakuro Games | | 1.00 | - | 1.0 |
| Suikoden: Tierkreis | | 1.00 | en es fr | 9.4 |
| Suite Life of Zack & Cody, The: Circle of Spies | | 1.00 | de en es fr it nl | 8.0 |
| Suite Life of Zack & Cody, The: Tipton Trouble | | 1.00 | en fr | 10.0 |
| Summon Night: Twin Age | | 1.00 | - | 8.5 |
| Super Black Bass Fishing | | 1.00 | - | 10.0 |
| Super Collapse! 3 | | 1.00 | - | 6.5 |
| Super Dodgeball Brawlers | | 1.00 | - | 8.5 |
| Super Fruit Fall | | 1.00 | - | none |
| Super Mario 64 DS | | 1.10 | - | 8.4 |
| Super Mario 64 DS (Wii U Virtual Console) | | 1.10 | - | 8.7 |
| Super Monkey Ball: Touch & Roll | | 1.00 | de en es fr it | 8.1 |
| Super Princess Peach | | 1.00 | - | 7.7 |
| Super Robot Taisen OG Saga: Endless Frontier | | 1.00 | - | 8.7 |
| Super Scribblenauts | | 1.00 | en es fr pt | 9.3 |
| Super Speed Machines | | 1.00 | - | 7.0 |
| Super Star Kartz | | 1.00 | en fr | none |
| Superman Returns | | 1.00 | de en es fr it | 6.3 |
| Surf's Up | | 1.10 | en es fr | none |
| Survivor | | 1.00 | - | 10.0 |
| Sushi Academy | | 1.00 | en es fr | none |
| Sushi Go-Round | | 1.00 | de en es fr it | none |
| Suzuki Super-Bikes II: Riding Challenge | | 1.00 | - | 10.0 |
