| Title | Region | Version | Languages | Rating |
| Sabre Wulf | | 1.0 | - | 8.4 |
| Sabrina the Teenage Witch: Potion Commotion | | 1.0 | en es fr | 1.0 |
| Salt Lake 2002 | | 1.0 | de en es fr it nl | 8.0 |
| Samurai Deeper Kyo | | 1.0 | - | 8.8 |
| Samurai Jack: The Amulet of Time | | 1.0 | - | 8.8 |
| Santa Clause 3, The: The Escape Clause | | 1.0 | - | 7.0 |
| Scooby-Doo | | 1.0 | - | 7.3 |
| Scooby-Doo 2: Monsters Unleashed | | 1.0 | - | 7.2 |
| Scooby-Doo and the Cyber Chase | | 1.0 | - | 8.3 |
| Scooby-Doo! Mystery Mayhem | | 1.0 | en fr | 8.5 |
| Scooby-Doo! Unmasked | | 1.0 | en fr | 7.4 |
| Scorpion King, The: Sword of Osiris | | 1.0 | - | 7.3 |
| Scrabble Blast! | | 1.0 | - | 8.0 |
| Scurge: Hive | | 1.0 | en es fr | 8.9 |
| SD Gundam Force | | 1.0 | - | 8.9 |
| Sea Trader: Rise of Taipan | | 1.0 | - | 6.7 |
| Secret Agent Barbie: Royal Jewels Mission | | 1.0 | - | 6.5 |
| SEGA Arcade Gallery | | 1.0 | - | 8.7 |
| SEGA Rally Championship | | 1.0 | - | 7.0 |
| SEGA Smash Pack | | 1.0 | - | 8.5 |
| Serious Sam Advance | | 1.0 | de en fr | 6.7 |
| Shaman King: Legacy of the Spirits - Soaring Hawk | | 1.0 | - | 8.0 |
| Shaman King: Legacy of the Spirits - Sprinting Wolf | | 1.0 | - | 7.0 |
| Shaman King: Master of Spirits | | 1.0 | - | 8.1 |
| Shaman King: Master of Spirits 2 | | 1.0 | - | 8.5 |
| Shamu's Deep Sea Adventures | | 1.0 | - | 5.0 |
Shantae Advance: Risky Revolution (Limited Run Games)  | | 1.0 | - | 9.5 |
| Shark Tale | | 1.0 | - | 7.3 |
| Shaun Palmer's Pro Snowboarder | | 1.0 | - | 7.0 |
| Shifting Gears: Road Trip | | 1.0 | - | 6.7 |
| Shining Force: Resurrection of the Dark Dragon | | 1.0 | - | 8.6 |
| Shining Soul | | 1.0 | - | 8.7 |
| Shining Soul II | | 1.0 | - | 8.9 |
| Shrek 2 | | 1.0 | - | 9.3 |
| Shrek 2: Beg for Mercy | | 1.0 | - | 8.2 |
| Shrek the Third | | 1.0 | - | 8.5 |
| Shrek: Hassle at the Castle | | 1.0 | de en es fr it nl | 8.7 |
| Shrek: Reekin' Havoc | | 1.0 | de en es fr it nl | 7.8 |
| Shrek: Smash n' Crash Racing | | 1.0 | - | 6.5 |
| Shrek: Super Slam | | 1.0 | - | 7.7 |
| Shrek: Swamp Kart Speedway | | 1.0 | de en es fr it nl | 7.8 |
| Shrek: Swamp Kart Speedway | | 1.1 | de en es fr it nl | 7.3 |
| Sigma Star Saga | | 1.0 | - | 8.5 |
| Sigma Star Saga DX (Limited Run Games) ⚠ | | 1.0 | - | none |
| Silent Scope | | 1.0 | de en es fr it | 6.3 |
| SimCity 2000 | | 1.1 | - | 8.3 |
| Simpsons, The: Road Rage | | 1.0 | - | 9.0 |
| Sims 2, The | | 1.0 | de en es fr it nl | 8.8 |
| Sims 2, The: Pets | | 1.0 | - | 4.6 |
| Sims, The: Bustin' Out | | 1.0 | de en es fr it nl | 7.2 |
| Sims, The: Bustin' Out | | 1.1 | de en es fr it nl | 8.5 |
| Sitting Ducks | | 1.0 | de en es fr it nl | 5.5 |
| Sky Dancers: They Magically Fly! | | 1.0 | - | 7.8 |
| Smashing Drive | | 1.0 | - | 7.6 |
| Smuggler's Run | | 1.0 | - | 6.2 |
| Snood | | 1.0 | - | 8.5 |
| Snood 2: On Vacation | | 1.0 | - | 5.5 |
| Soccer Kid | | 1.0 | - | 8.7 |
| Soccer Mania | | 1.0 | da de en es fr it nl sv | 9.5 |
| Sonic Advance | | 1.0 | en ja | 8.5 |
| Sonic Advance 2 | | 1.0 | de en es fr it ja | 8.7 |
| Sonic Advance 3 | | 1.0 | de en es fr it ja | 8.7 |
| Sonic Battle | | 1.0 | de en es fr it ja | 8.8 |
| Sonic Pinball Party | | 1.0 | de en es fr it ja | 8.7 |
| Sonic The Hedgehog: Genesis | | 1.0 | - | 3.2 |
| Sound of Thunder, A | | 1.0 | de en es fr it | 8.9 |
| Space Channel 5: Ulala's Cosmic Attack | | 1.0 | - | 6.3 |
| Space Invaders | | 1.0 | - | 7.6 |
| Spider-Man | | 1.0 | - | 6.4 |
| Spider-Man 2 | | 1.0 | - | 8.0 |
| Spider-Man 3 | | 1.0 | - | 8.0 |
| Spider-Man: Battle for New York | | 1.0 | - | 7.9 |
| Spider-Man: Mysterio's Menace | | 1.0 | - | 8.8 |
| Spirit: Stallion of the Cimarron - Search for Homeland | | 1.0 | - | 5.0 |
| Spirits & Spells | | 1.0 | - | 8.3 |
| SpongeBob SquarePants Movie, The | | 1.0 | - | 9.0 |
| SpongeBob SquarePants: Battle for Bikini Bottom | | 1.0 | - | 8.7 |
| SpongeBob SquarePants: Creature from the Krusty Krab | | 1.0 | - | 8.2 |
| SpongeBob SquarePants: Lights, Camera, Pants! | | 1.0 | - | 7.5 |
| SpongeBob SquarePants: Revenge of the Flying Dutchman | | 1.0 | - | 8.8 |
| SpongeBob SquarePants: SuperSponge | | 1.0 | - | 8.3 |
| SpongeBob's Atlantis SquarePantis | | 1.0 | - | 8.8 |
| Sports Illustrated for Kids: Baseball | | 1.0 | - | 5.0 |
| Sports Illustrated for Kids: Football | | 1.0 | - | 5.5 |
| Sportsmans Pack 2 in 1: Cabela's Big Game Hunter + Rapala Pro Fishing | | 1.0 | - | 5.0 |
| Spy Hunter | | 1.0 | de en es fr ja | 8.5 |
| Spy Kids 3-D: Game Over | | 1.0 | - | 7.8 |
| Spy Kids Challenger | | 1.0 | - | 8.5 |
| Spy Muppets: License to Croak | | 1.0 | de en es fr it nl | 7.3 |
| Spyro 2: Season of Flame | | 1.0 | - | 8.6 |
| Spyro Orange: The Cortex Conspiracy | | 1.1 | - | 6.3 |
| Spyro Superpack: Spyro - Season of Ice + Spyro 2 - Season of Flame | | 1.0 | - | 5.0 |
| Spyro: Attack of the Rhynocs | | 1.0 | - | 8.8 |
| Spyro: Season of Ice | | 1.0 | - | 7.0 |
| SSX 3 | | 1.0 | - | 7.0 |
| SSX Tricky | | 1.0 | de en fr | 8.0 |
| Stadium Games | | 1.0 | - | 8.0 |
| Star Wars Trilogy: Apprentice of the Force | | 1.0 | en es fr | 7.9 |
| Star Wars: Episode II - Attack of the Clones | | 1.0 | - | 5.5 |
| Star Wars: Episode III - Revenge of the Sith | | 1.0 | en es fr | 8.9 |
| Star Wars: Flight of the Falcon | | 1.0 | - | 5.6 |
| Star Wars: Jedi Power Battles | | 1.0 | - | 7.3 |
| Star Wars: The New Droid Army | | 1.0 | - | 7.7 |
| Star X | | 1.0 | de en es fr it nl | 8.6 |
| Starsky & Hutch | | 1.0 | - | 4.0 |
| Strawberry Shortcake: Summertime Adventure | | 1.0 | - | 1.0 |
| Strawberry Shortcake: Summertime Adventure - Special Edition | | 1.0 | - | 6.0 |
| Strawberry Shortcake: Sweet Dreams | | 1.0 | - | none |
| Street Fighter Alpha 3 | | 1.0 | - | 8.9 |
| Street Jam Basketball | | 1.0 | - | 7.0 |
| Street Racing Syndicate | | 1.0 | - | 7.0 |
| Strike Force Hydra | | 1.0 | - | 8.0 |
| Stuart Little 2 | | 1.0 | - | 7.6 |
| Stuntman | | 1.0 | en es fr | 6.3 |
| Suite Life of Zack & Cody, The: Tipton Caper | | 1.0 | en fr | 5.0 |
| Sum of All Fears, The | | 1.0 | de en es fr it | 7.8 |
| Summon Night: Swordcraft Story | | 1.0 | - | 8.6 |
| Summon Night: Swordcraft Story 2 | | 1.0 | - | 8.6 |
| Super Army War | | 1.0 | - | 7.0 |
| Super Bubble Pop | | 1.0 | - | none |
| Super Bubble Pop (Evercade) | | 1.0 | - | none |
| Super Bust-A-Move | | 1.0 | en es fr | 7.0 |
| Super Collapse! II | | 1.0 | - | none |
| Super Dodge Ball Advance | | 1.1 | - | 8.3 |
| Super Dropzone: Intergalactic Rescue Mission | | 1.0 | - | 5.5 |
| Super Duper Sumos | | 1.0 | - | 8.9 |
| Super Ghouls'n Ghosts | | 1.0 | - | 7.8 |
| Super Ghouls'n Ghosts (Virtual Console) | | 1.0 | - | none |
| Super Hornet FA 18F | | 1.0 | - | 9.5 |
| Super Mario Advance | | 1.0 | - | 9.0 |
| Super Mario Advance (Virtual Console) | | 1.0 | - | 8.0 |
| Super Mario Advance 2: Super Mario World | | 1.0 | - | 8.5 |
| Super Mario Advance 3: Yoshi's Island | | 1.0 | - | 8.5 |
| Super Mario Advance 3: Yoshi's Island (Virtual Console) | | 1.0 | - | 8.0 |
| Super Mario Advance 4: Super Mario Bros. 3 | | 1.1 | - | 8.5 |
| Super Mario Advance 4: Super Mario Bros. 3 | | 1.0 | - | 9.3 |
| Super Mario Advance 4: Super Mario Bros. 3 (Switch Online) | | 1.1 | - | 9.5 |
| Super Mario Advance 4: Super Mario Bros. 3 (Virtual Console) | | 1.1 | - | 8.4 |
| Super Monkey Ball Jr. | | 1.0 | - | 8.5 |
| Super Puzzle Fighter II | | 1.1 | - | 8.5 |
| Super Robot Taisen: Original Generation | | 1.0 | - | 9.7 |
| Super Robot Taisen: Original Generation 2 | | 1.0 | - | 9.6 |
| Super Street Fighter II Turbo: Revival | | 1.0 | - | 9.1 |
| Super Street Fighter II Turbo: Revival (Virtual Console) | | 1.0 | - | none |
| Superman Returns: Fortress of Solitude | | 1.0 | de en es fr it | 9.5 |
| Superman: Countdown to Apokolips | | 1.0 | - | 8.2 |
| Surf's Up | | 1.0 | en es fr | 9.5 |
| Sword of Mana | | 1.0 | - | 8.8 |
