| Title | Cart Size
(Mbit) | Rating |
| Sabre Wulf | 64 | 8.0 |
| Salt Lake 2002 | 32 | none |
| Samurai Jack: The Amulet of Time | 64 | 9.3 |
| Santa Clause 3, The: The Escape Clause | 64 | 5.5 |
| Scooby-Doo 2: Monsters Unleashed | 64 | 5.3 |
| Scooby-Doo and the Cyber Chase | 32 | 5.0 |
| Scooby-Doo!: Mystery Mayhem | 32 | 7.0 |
| Scooby-Doo!: Unmasked | 64 | 8.0 |
| Scorpion King, The: Sword of Osiris | 32 | 6.3 |
| Scrabble Blast! | 32 | none |
| Scurge: Hive | 128 | 9.3 |
| SD Gundam Force | 64 | 7.0 |
| Secret Agent Barbie: Royal Jewels Mission | 32 | 5.5 |
| Sega Arcade Gallery | 64 | 9.0 |
| Sega Rally Championship | 64 | none |
| Sega Smash Pack | 64 | 7.0 |
| Serious Sam Advance | 64 | 10.0 |
| Shaman King: Legacy of the Spirits - Soaring Hawk | 128 | none |
| Shaman King: Legacy of the Spirits - Sprinting Wolf | 128 | 10.0 |
| Shaman King: Master of Spirits | 128 | 8.5 |
| Shaman King: Master of Spirits 2 | 128 | none |
| Shamu's Deep Sea Adventures | 256 | none |
| Shark Tale | 64 | 6.3 |
| Shaun Palmer's Pro Snowboarder | 64 | none |
| Shining Force: Resurrection of the Dark Dragon | 64 | 8.2 |
| Shining Soul | 64 | 8.0 |
| Shining Soul II | 128 | 9.7 |
| Shrek 2 | 64 | 10.0 |
| Shrek 2: Beg for Mercy | 64 | 9.3 |
| Shrek the Third | 64 | 9.5 |
| Shrek: Hassle at the Castle | 32 | 10.0 |
| Shrek: Reekin' Havoc | 64 | 7.8 |
| Shrek: Smash n' Crash Racing | 64 | 6.5 |
| Shrek: Super Slam | 64 | 8.5 |
| Shrek: Swamp Kart Speedway | 64 | 9.0 |
| Sigma Star Saga | 64 | 9.0 |
| Silent Scope | 64 | 8.0 |
| SimCity 2000 | 32 | 10.0 |
Simpsons, The: Road Rage  | 64 | 7.3 |
| Sims 2, The | 256 | 8.3 |
| Sims 2, The: Pets | 256 | 2.5 |
| Sims, The: Bustin' Out | 128 | 8.4 |
| Sitting Ducks | 32 | none |
| Sky Dancers: They Magically Fly! | 32 | 10.0 |
| Smashing Drive | 64 | 9.0 |
| Smuggler's Run | 64 | 5.7 |
| Snood | 32 | 7.0 |
| Snood 2: On Vacation | 32 | none |
| Soccer Kid | 32 | 7.0 |
| Sonic Advance | 64 | 8.6 |
| Sonic Advance 2 | 128 | 8.9 |
| Sonic Advance 3 | 128 | 8.7 |
| Sonic Battle | 128 | 8.7 |
| Sonic Pinball Party | 64 | 7.7 |
| Sonic The Hedgehog: Genesis | 32 | 3.0 |
| Sound of Thunder, A | 64 | none |
| Space Channel 5: Ulala's Cosmic Attack | 64 | 4.8 |
| Space Invaders | 32 | 8.5 |
| Spider-Man | 64 | 5.6 |
| Spider-Man 2 | 128 | none |
| Spider-Man 3 | 64 | 7.3 |
| Spider-Man: Battle for New York | 128 | 8.0 |
| Spider-Man: Mysterio's Menace | 64 | 9.0 |
| Spirit: Stallion of the Cimarron - Search for Homeland | 32 | none |
| Spirits & Spells | 32 | 9.0 |
| SpongeBob SquarePants Movie, The | 64 | 7.8 |
| SpongeBob SquarePants: Battle for Bikini Bottom | 64 | 8.8 |
| SpongeBob SquarePants: Creature from the Krusty Krab | 64 | 7.0 |
| SpongeBob SquarePants: Lights, Camera, Pants! | 32 | 9.0 |
| SpongeBob SquarePants: Revenge of the Flying Dutchman | 64 | 8.0 |
| SpongeBob SquarePants: SuperSponge | 32 | 7.0 |
| Sports Illustrated for Kids: Baseball | 32 | none |
| Sports Illustrated for Kids: Football | 32 | none |
| Sportsman's Pack | 64 | 9.0 |
| Spy Hunter | 64 | none |
| Spy Kids 3-D: Game Over | 64 | none |
| Spy Kids Challenger | 32 | 5.0 |
| Spy Muppets: License to Croak | 64 | 6.0 |
| Spyro 2: Season of Flame | 64 | 9.5 |
| Spyro Orange: The Cortex Conspiracy | 128 | 3.5 |
| Spyro: Attack of the Rhynocs | 64 | 8.7 |
| Spyro: Season of Ice | 64 | 8.0 |
| SSX 3 | 64 | 7.0 |
| SSX Tricky | 64 | none |
| Stadium Games | 32 | none |
| Star Wars Trilogy: Apprentice of the Force | 64 | 8.5 |
| Star Wars: Episode II - Attack of the Clones | 64 | 4.0 |
| Star Wars: Episode III - Revenge of the Sith | 64 | 9.6 |
| Star Wars: Flight of the Falcon | 64 | 7.5 |
| Star Wars: Jedi Power Battles | 64 | 6.0 |
| Star Wars: The New Droid Army | 64 | 9.0 |
| Star X | 64 | none |
| Strawberry Shortcake: Summertime Adventure | 32 | none |
| Strawberry Shortcake: Summertime Adventure - Special Edition | 128 | 6.0 |
| Strawberry Shortcake: Sweet Dreams | 32 | none |
| Street Fighter Alpha 3 | 64 | 8.0 |
| Street Jam Basketball | 32 | none |
| Street Racing Syndicate | 32 | 5.5 |
| Strike Force Hydra | 32 | none |
| Stuart Little 2 | 64 | 7.0 |
| Stuntman | 32 | 8.0 |
| Suite Life of Zack & Cody, The: Tipton Caper | 64 | none |
| Sum of All Fears, The | 64 | none |
| Summon Night: Swordcraft Story | 64 | 9.5 |
| Summon Night: Swordcraft Story 2 | 128 | 8.9 |
| Super Army War | 32 | none |
| Super Bubble Pop | 32 | none |
| Super Bust-A-Move | 32 | none |
| Super Collapse! II | 32 | none |
| Super Dodge Ball Advance | 32 | 9.8 |
| Super Dropzone: Intergalactic Rescue Mission | 32 | none |
| Super Duper Sumos | 32 | 8.2 |
| Super Ghouls'n Ghosts | 32 | 9.0 |
| Super Hornet FA 18F | 32 | none |
| Super Mario Advance | 32 | 8.9 |
| Super Mario Advance 2: Super Mario World | 32 | 8.8 |
| Super Mario Advance 3: Yoshi's Island | 32 | 9.6 |
| Super Mario Advance 4: Super Mario Bros. 3 | 32 | 8.7 |
| Super Monkey Ball Jr. | 32 | 8.4 |
| Super Puzzle Fighter II | 64 | 8.0 |
| Super Robot Taisen: Original Generation | 128 | 9.0 |
| Super Robot Taisen: Original Generation 2 | 128 | 9.3 |
| Super Street Fighter II Turbo: Revival | 64 | 8.0 |
| Superman Returns: Fortress of Solitude | 128 | none |
| Superman: Countdown to Apokolips | 64 | none |
| Surf's Up | 64 | none |
| Sword of Mana | 128 | 8.7 |
