| Title | Region | Version | Languages | Rating |
| S.L.A.I.: Steel Lancer Arena International |  | 1.02 | - | 8.8 |
| Sakura Wars: So Long, My Love (English Voice Over) | | 1.0 | - | 8.4 |
| Salt Lake 2002 | | 1.01 | - | 5.3 |
| Samurai Champloo: Sidetracked | | 1.0 | - | 8.7 |
Samurai Jack: The Shadow of Aku  | | 1.03 | - | 8.5 |
| Samurai Shodown Anthology | | 1.01 | - | 8.3 |
| Samurai Warriors | | 1.0 | - | 8.7 |
| Samurai Warriors 2 | | 1.01 | - | 9.5 |
| Samurai Warriors 2: Empires | | 1.0 | - | 8.8 |
| Samurai Warriors 2: Xtreme Legends | | 1.02 | - | 9.3 |
| Samurai Warriors: Xtreme Legends | | 1.0 | - | 8.7 |
| Samurai Western | | 1.01 | - | 8.2 |
| Saturday Night Speedway | | 1.0 | - | 8.3 |
| Savage Skies | | 1.02 | - | 8.3 |
| SBK: Superbike World Championship | | 1.01 | - | 4.0 |
| Scaler | | 1.0 | en fr | 9.6 |
| Scarface: The World Is Yours | | 1.0 | - | 7.6 |
| Scooby-Doo! and the Spooky Swamp | | 1.01 | en es fr | 8.3 |
| Scooby-Doo! First Frights | | 1.0 | en es fr | 8.3 |
| Scooby-Doo! Mystery Mayhem | | 1.0 | en fr | 8.3 |
| Scooby-Doo! Night of 100 Frights | | 1.01 | - | 9.3 |
| Scooby-Doo! Unmasked | | 1.01 | en fr | 8.9 |
| Score International Baja 1000: The Official Game | | 1.0 | - | 6.0 |
| Scorpion King, The: Rise of the Akkadian | | 1.03 | - | 6.0 |
| SD Gundam Force: Showdown! | | 1.01 | - | 9.7 |
| Sea Monsters: A Prehistoric Adventure | | 1.01 | - | 8.7 |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | | 1.0 | - | 6.0 |
| Second Sight | | 1.0 | - | 9.6 |
| Secret Agent Clank | | 1.0 | de en es fr it | 7.2 |
| Secret Saturdays, The: Beasts of the 5th Sun | | 1.01 | de en es fr it | none |
| Secret Service | | 1.01 | - | 5.0 |
| Secret Weapons over Normandy | | 1.01 | - | 9.5 |
| Seek and Destroy | | 1.01 | - | 8.5 |
| Sega Bass Fishing Duel | | 1.02 | - | 8.0 |
| Sega Classics Collection | | 1.01 | - | 8.3 |
| Sega Genesis Collection | | 1.01 | - | 9.4 |
| Sega Soccer Slam | | 1.0 | - | 8.5 |
| Sega Sports Tennis | | 1.01 | - | 8.0 |
| Sega Superstars | | 1.0 | - | 9.7 |
| Sega Superstars Tennis | | 1.01 | de en es fr it | 8.8 |
| Serious Sam: Next Encounter | | 1.01 | - | 9.1 |
| Seven Samurai 20XX | | 1.0 | - | 7.5 |
| Shadow Hearts | | 1.0 | - | 8.5 |
| Shadow Hearts: Covenant | | 1.0 | - | 9.0 |
| Shadow Hearts: From the New World | | 1.01 | - | 8.4 |
| Shadow Man: 2econd Coming | | 1.03 | - | 8.8 |
| Shadow of Destiny | | 1.1 | - | 9.0 |
| Shadow of Rome | | 1.03 | - | 9.6 |
| Shadow of the Colossus | | 1.0 | - | 8.6 |
| Shadow the Hedgehog | | 1.02 | de en es fr it ja | 6.2 |
| Shaun Palmer's Pro Snowboarder | | 1.0 | - | 8.7 |
| Shaun White Snowboarding | | 1.01 | - | none |
| ShellShock: Nam '67 | | 2.0 | - | 9.2 |
| Shepherd's Crossing | | 1.0 | - | 8.7 |
| Shield, The: The Game | | 1.01 | - | 7.0 |
| Shifters | | 1.02 | - | 7.5 |
| Shin Megami Tensei: Devil Summoner - Raidou Kuzunoha vs. the Soulless Army | | 1.0 | - | 8.4 |
| Shin Megami Tensei: Devil Summoner 2 - Raidou Kuzunoha vs. King Abaddon | | 1.0 | - | 8.5 |
| Shin Megami Tensei: Digital Devil Saga | | 1.0 | - | 7.6 |
| Shin Megami Tensei: Digital Devil Saga 2 | | 1.0 | - | 9.3 |
| Shin Megami Tensei: Nocturne | | 1.01 | - | 8.0 |
| Shin Megami Tensei: Persona 3 | | 1.0 | - | 7.8 |
| Shin Megami Tensei: Persona 3 FES | | 1.0 | - | 8.6 |
| Shin Megami Tensei: Persona 4 | | 1.0 | - | 8.1 |
| Shining Force EXA | | 1.0 | - | 8.8 |
| Shining Force Neo | | 1.0 | - | 9.2 |
| Shining Tears | | 1.0 | - | 9.0 |
| Shinobi | | 1.0 | en ja | 9.2 |
| Shonen Jump's One Piece: Grand Adventure | | 1.01 | - | 9.6 |
| Shonen Jump's One Piece: Grand Battle | | 1.0 | - | 6.8 |
| Shonen Jump's One Piece: Pirates' Carnival | | 1.0 | - | 8.6 |
| Shonen Jump's Shaman King: Power of Spirit | | 1.0 | - | 9.0 |
| Short Track Racing: Trading Paint | | 1.0 | - | 5.5 |
| Showdown: Legends of Wrestling | | 1.01 | - | 8.3 |
| Shox | | 1.0 | en es fr | 8.1 |
| Shrek 2 | | 1.02 | - | 9.3 |
| Shrek Super Party | | 1.0 | - | 7.0 |
| Silent Hill 2 | | 2.01 | de en es fr it ja | 8.7 |
| Silent Hill 3 | | 1.02 | de en es fr it ja ko | 7.9 |
| Silent Hill 4: The Room | | 1.0 | en ja | 7.8 |
| Silent Hill Origins | | 1.0 | de en es fr it | 7.3 |
| Silent Hill: Shattered Memories | | 1.0 | en es fr | 7.6 |
| Silent Line: Armored Core | | 1.0 | - | 9.6 |
| Silent Scope | | 1.0 | - | 7.7 |
| Silent Scope 2: Dark Silhouette | | 1.0 | en es ja | 8.0 |
| Silent Scope 3 | | 1.0 | en es ja | 6.0 |
| Silpheed: The Lost Planet | | 1.2 | - | 8.5 |
| Simpsons Game, The | | 1.0 | - | 7.3 |
| Simpsons Skateboarding, The | | 1.01 | - | 6.5 |
| Simpsons, The: Hit & Run | | 1.01 | - | 8.1 |
| Simpsons, The: Road Rage | | 1.0 | - | 8.9 |
| Sims 2, The | | 1.0 | - | 8.0 |
| Sims 2, The: Castaway | | 1.0 | - | 9.1 |
| Sims 2, The: Pets | | 1.0 | - | 7.6 |
| Sims, The | | 1.0 | - | 8.9 |
| Sims, The: Bustin' Out | | 1.0 | - | 7.0 |
| SingStar '80s | | 1.0 | - | 5.0 |
| SingStar '90s | | 1.0 | - | none |
| SingStar ABBA | | 1.0 | - | none |
| SingStar Amped | | 1.0 | - | none |
| SingStar Country | | 1.0 | - | none |
| SingStar Latino | | 1.0 | - | none |
| SingStar Legends | | 1.0 | - | none |
| SingStar Pop | | 1.0 | - | none |
| SingStar Pop Vol. 2 | | 1.0 | - | none |
| SingStar Queen | | 1.0 | - | 8.5 |
| SingStar Rocks! | | 1.0 | - | none |
| Siren | | 1.0 | - | 8.3 |
| Sitting Ducks | | 1.0 | - | 7.2 |
| Ski and Shoot | | 1.01 | en fr | 8.0 |
| Ski-Doo Snow X Racing | | 1.0 | - | none |
| Sky Odyssey | | 1.1 | - | 8.8 |
| SkyGunner | | 1.01 | - | 8.4 |
| Sled Storm | | 1.0 | - | 8.5 |
| Sly 2: Band of Thieves | | 1.0 | - | 8.1 |
| Sly 3: Honor Among Thieves | | 1.0 | - | 7.9 |
| Sly Cooper and the Thievius Raccoonus | | 1.0 | - | 7.9 |
| Smash Cars | | 1.03 | - | 8.0 |
| Smash Court Tennis: Pro Tournament | | 1.0 | - | none |
| Smash Court Tennis: Pro Tournament 2 | | 1.0 | - | 8.4 |
| Smuggler's Run | | 1.0 | - | 6.7 |
| Smuggler's Run 2: Hostile Territory | | 1.0 | - | 7.2 |
| Sniper Elite | | 1.02 | - | 8.8 |
| SNK Arcade Classics Vol. 1 | | 1.01 | - | 8.0 |
| SnoCross 2 featuring Blair Morgan | | 1.04 | - | 4.0 |
| Snoopy vs. the Red Baron | | 1.01 | - | 9.1 |
| Soccer America: International Cup | | 1.0 | en es | none |
| Soccer Mania | | 1.0 | - | 9.4 |
| SOCOM 3: U.S. Navy SEALs | | 1.0 | - | 8.5 |
| SOCOM II: U.S. Navy SEALs | | 1.02 | - | 9.3 |
| SOCOM: U.S. Navy SEALs | | 3.0 | - | 9.0 |
| SOCOM: U.S. Navy SEALs - Combined Assault | | 1.0 | - | 8.9 |
| Soldier of Fortune: Gold Edition | | 1.2 | - | 8.3 |
| Sonic Heroes | | 1.0 | de en es fr it ja | 8.2 |
| Sonic Mega Collection Plus | | 1.0 | - | 8.6 |
| Sonic Riders | | 1.0 | de en es fr it ja | 8.3 |
| Sonic Riders: Zero Gravity | | 1.0 | de en es fr it ja | 7.8 |
| Sonic Unleashed | | 1.01 | de en es fr it ja | 8.1 |
| Sony DVD Test Disc |  | 1.0 | - | 8.2 |
| Sopranos, The: Road to Respect | | 1.01 | - | 8.2 |
| Soul Nomad & the World Eaters | | 1.0 | - | 8.8 |
| Soulcalibur II | | 1.0 | - | 9.6 |
| Soulcalibur III | | 1.01 | - | 9.0 |
| Space Channel 5: Special Edition | | 1.0 | - | 8.5 |
| Space Chimps | | 1.03 | - | 7.8 |
| Spartan: Total Warrior | | 1.02 | - | 9.2 |
| Spawn: Armageddon | | 1.0 | - | 9.5 |
| Speed Kings | | 1.0 | - | 7.0 |
| Speed Racer | | 1.02 | en es fr pt | 9.1 |
| Sphinx and the Cursed Mummy | | 1.0 | - | 9.8 |
| Spider-Man | | 2.01 | - | 8.3 |
| Spider-Man 2 | | 1.01 | - | 7.5 |
| Spider-Man 3 | | 2.0 | - | 7.5 |
| Spider-Man: Friend or Foe | | 1.01 | - | 8.6 |
| Spider-Man: Web of Shadows - Amazing Allies Edition | | 1.01 | - | 6.6 |
| Spiderwick Chronicles, The | | 1.0 | - | 9.5 |
| Splashdown | | 2.01 | - | 6.9 |
| Splashdown: Rides Gone Wild | | 1.0 | - | 9.6 |
| Sprint Cars 2: Showdown at Eldora | | 1.0 | - | none |
| Sprint Cars: Road to Knoxville | | 1.02 | - | 6.8 |
| Spy Fiction | | 1.0 | - | 8.5 |
| SpyHunter | | 1.0 | - | 9.3 |
| SpyHunter 2 | | 1.01 | - | 8.7 |
| SpyHunter: Nowhere to Run | | 1.0 | - | 7.0 |
| Spyro: A Hero's Tail | | 1.0 | - | 9.2 |
| Spyro: Enter the Dragonfly | | 3.0 | - | 5.7 |
| SRS: Street Racing Syndicate | | 2.0 | - | 8.0 |
| SSX | | 1.0 | - | 9.2 |
| SSX 3 | | 1.0 | - | 8.2 |
| SSX on Tour | | 1.0 | - | 9.1 |
| SSX Tricky | | 1.0 | - | 8.0 |
| Stacked with Daniel Negreanu | | 1.01 | - | 9.0 |
| Star Ocean: Till the End of Time | | 1.0 | - | 7.8 |
| Star Trek: Conquest | | 1.01 | - | 8.8 |
| Star Trek: Encounters | | 1.01 | - | 8.7 |
| Star Trek: Shattered Universe | | 1.01 | - | 5.8 |
| Star Trek: Voyager - Elite Force | | 1.1 | - | 7.3 |
| Star Wars: Battlefront | | 1.02 | - | 7.9 |
| Star Wars: Battlefront II | | 2.01 | - | 8.2 |
| Star Wars: Bounty Hunter | | 1.02 | - | 8.9 |
| Star Wars: Episode III - Revenge of the Sith | | 1.03 | - | 8.7 |
| Star Wars: Jedi Starfighter | | 2.1 | - | 9.3 |
| Star Wars: Racer Revenge | | 1.1 | - | 7.3 |
| Star Wars: Starfighter | | 1.0 | - | 8.0 |
| Star Wars: Starfighter | | 1.0 | - | 8.0 |
| Star Wars: Super Bombad Racing | | 1.03 | de en es fr it | 7.5 |
| Star Wars: The Clone Wars | | 1.03 | - | 8.5 |
| Star Wars: The Clone Wars - Republic Heroes | | 1.0 | - | 6.2 |
| Star Wars: The Force Unleashed | | 1.02 | en fr | 9.4 |
| Starsky & Hutch | | 1.01 | - | 9.2 |
| State of Emergency | | 2.0 | - | 7.9 |
| State of Emergency 2 | | 1.02 | - | 6.8 |
| Steambot Chronicles | | 1.0 | - | 9.3 |
| Stella Deus: The Gate of Eternity | | 1.0 | - | 9.0 |
| Stolen | | 1.03 | en es fr | 8.0 |
| Strawberry Shortcake: The Sweet Dreams Game | | 1.02 | - | 9.2 |
| Street Fighter Alpha Anthology | | 1.01 | - | 7.3 |
| Street Fighter Anniversary Collection | | 1.02 | - | 9.1 |
| Street Fighter EX3 | | 1.0 | - | 7.4 |
| Street Hoops | | 1.0 | - | 8.6 |
