| Title | Region | Version | Languages | Rating |
S.O.S: Sink or Swim  |  | 1.0 | - | 7.6 |
| SA1 Demonstration Program (Tech Demo) | - | 1.0 | - | 10.0 |
| Samurai Shodown | | 1.0 | - | 7.7 |
| Saturday Night Slam Masters | | 1.0 | - | 8.5 |
| Scooby-Doo Mystery | | 1.0 | - | 7.3 |
| seaQuest DSV | | 1.0 | - | 5.0 |
| Secret of Evermore | | 1.0 | - | 7.8 |
| Secret of Mana | | 1.0 | - | 8.7 |
| Secret of Mana (Collection of Mana) |  | 1.0 | de | 10.0 |
| Secret of Mana (Collection of Mana) | | 1.1 | fr | 10.0 |
| Secret of Mana (Virtual Console) | | 1.0 | - | none |
| Seiken Densetsu 3 T | - | 1.0 | - | 8.7 |
| Sextris (Pirate) | | 1.0 | - | none |
| Shadowrun | | 1.0 | - | 8.7 |
| Shanghai II: Dragon's Eye | | 1.0 | - | 5.4 |
| Shaq-Fu | | 1.0 | - | 6.0 |
| Shien's Revenge | | 1.0 | - | 5.2 |
| Sid Meier's Civilization | | 1.0 | - | 8.1 |
| Side Pocket | | 1.0 | - | 8.1 |
| Side Pocket (Evercade) | | 1.0 | - | none |
| SimAnt: The Electronic Ant Colony | | 1.0 | - | 8.1 |
| SimCity | | 1.0 | - | 8.6 |
| SimCity 2000: The Ultimate City Simulator | | 1.0 | - | 8.6 |
| SimEarth: The Living Planet | | 1.0 | - | 7.6 |
| Simpsons, The: Bart's Nightmare | | 1.0 | - | 7.6 |
| Skuljagger: Revolt of the Westicans | | 1.0 | - | 5.3 |
| Skuljagger: Revolt of the Westicans (Evercade) | | 1.0 | - | none |
| Skyblazer | | 1.0 | - | 8.0 |
| Smart Ball | | 1.0 | - | 5.2 |
| Snow White in Happily Ever After | | 1.0 | - | 2.8 |
| Soccer Kid (Evercade) | | 1.0 | de en es fr it | none |
| Soldiers of Fortune | | 1.0 | - | 6.7 |
| Sonic Blast Man | | 1.0 | - | 6.8 |
| Sonic Blast Man II | | 1.0 | - | 7.6 |
| Sonic The Hedgehog (Pirate) | | 1.0 | - | none |
| Sonic The Hedgehog (Pirate) (Alt) | | 1.0 | - | none |
| SOS | | 1.0 | - | 6.5 |
| Soul Blade (Pirate) | | 1.0 | - | none |
| Soul Blazer | | 1.0 | - | 8.6 |
| Soul Edge vs Samurai (Pirate) | | 1.0 | - | none |
| Space Ace | | 1.0 | - | 2.7 |
| Space Football: One on One | | 1.0 | - | 6.5 |
| Space Invaders | | 1.0 | - | 8.6 |
| Space Megaforce | | 1.0 | - | 8.5 |
| Spanky's Quest | | 1.0 | - | 7.5 |
| Sparkster | | 1.0 | - | 8.6 |
| Spectre | | 1.0 | - | 6.4 |
| Speed Racer | | 1.0 | - | 7.5 |
| Speedy Gonzales: Los Gatos Bandidos | | 1.1 | - | 6.4 |
| Spider-Man | | 1.0 | - | 7.9 |
| Spider-Man: Venom - Maximum Carnage | | 1.0 | - | 8.8 |
| Spider-Man: X-Men - Arcade's Revenge | | 1.0 | - | 7.2 |
| Spindizzy Worlds | | 1.0 | - | 7.4 |
| Sporting News Baseball, The | | 1.0 | - | 5.5 |
| Sports Illustrated: Championship Football & Baseball | | 1.0 | - | 6.3 |
| Squirrel (Pirate) | | 1.0 | - | none |
| ST010 (Enhancement Chip) |  | 1.0 | - | 10.0 |
| Star Fox | | 1.2 | - | 8.9 |
| Star Fox 2 (Classic Mini, Switch Online) |  | 1.0 | - | 8.8 |
| Star Ocean T | - | 1.0 | - | 8.5 |
| Star Trek: Deep Space Nine - Crossroads of Time | | 1.0 | - | 7.0 |
| Star Trek: Starfleet Academy - Starship Bridge Simulator | | 1.0 | - | 7.1 |
| Star Trek: The Next Generation - Future's Past | | 1.0 | - | 8.1 |
| Stargate | | 1.0 | - | 7.8 |
| Steel Talons | | 1.0 | - | 6.0 |
| Sterling Sharpe: End 2 End | | 1.0 | - | 3.0 |
| Stone Protectors | | 1.0 | - | 8.2 |
| Street Combat | | 1.0 | - | 7.2 |
| Street Fighter Alpha 2 | | 1.0 | - | 8.1 |
| Street Fighter EX Plus Alpha (Pirate) | | 1.0 | - | none |
| Street Fighter II | | 1.0 | - | 8.5 |
| Street Fighter II (Capcom Town) | | 1.0 | - | 7.0 |
| Street Fighter II (Virtual Console) | | 1.0 | - | none |
| Street Fighter II Turbo | | 1.1 | - | 8.6 |
| Street Fighter II Turbo (Virtual Console) | | 1.1 | - | none |
| Street Fighter V (Pirate) | | 1.0 | - | none |
| Street Racer | | 1.0 | - | 7.9 |
| Street Racer (Evercade) | | 1.0 | - | none |
| Street Racer (GOG) | | 1.0 | - | none |
| Street Sports: Jammit | | 1.0 | - | 5.5 |
| Street Sports: Street Hockey '95 | | 1.0 | - | 5.7 |
| Strike Gunner S.T.G | | 1.0 | - | 8.8 |
| Stunt Race FX | | 1.1 | - | 8.3 |
| Sunset Riders | | 1.0 | - | 8.6 |
| Super Adventure Island | | 1.0 | - | 7.9 |
| Super Adventure Island II | | 1.0 | - | 9.4 |
| Super Alfred Chicken | | 1.0 | - | 6.3 |
| Super Aquatic Games Starring the Aquabats, The | | 1.0 | - | 3.4 |
| Super Baseball 2020 | | 1.0 | - | 8.1 |
| Super Baseball Simulator 1.000 | | 1.0 | - | 9.2 |
| Super Bases Loaded | | 1.0 | - | 6.8 |
| Super Bases Loaded 2 | | 1.0 | - | 7.8 |
| Super Bases Loaded 3: License to Steal | | 1.0 | - | 6.2 |
| Super Batter Up | | 1.0 | - | 6.9 |
| Super Battleship | | 1.0 | - | 7.7 |
| Super Battletank 2 | | 1.0 | - | 8.0 |
| Super Black Bass | | 1.0 | - | 8.4 |
| Super Bomberman | | 1.0 | - | 8.7 |
| Super Bomberman 2 | | 1.0 | - | 8.7 |
| Super Bonk | | 1.0 | - | 8.2 |
| Super Bowling | | 1.0 | - | 8.1 |
| Super Buster Bros. | | 1.1 | - | 8.0 |
| Super Caesars Palace | | 1.0 | - | 8.6 |
| Super Campeones (Pirate) | | 1.0 | es | none |
| Super Campeones 4 (Pirate) | | 1.0 | es | none |
| Super Castlevania IV | | 1.0 | - | 8.5 |
| Super Castlevania IV (Castlevania Anniversary Collection) | | 1.0 | - | 10.0 |
| Super Castlevania IV (Virtual Console) | | 1.0 | - | 10.0 |
| Super Chase H.Q. | | 1.0 | - | 6.7 |
| Super Conflict | | 1.0 | - | 9.0 |
| Super Descentralizado 1995 (Pirate) | | 1.0 | es | none |
| Super Descentralizado II (Pirate) | | 1.0 | es | none |
| Super Double Dragon | | 1.0 | - | 8.6 |
| Super Game Boy | | 1.1 | en | none |
| Super Game Boy | | 1.2 | - | 9.4 |
| Super Game Boy SGB-CPU (Enhancement Chip) | | 1.0 | - | 10.0 |
| Super Ghouls 'N Ghosts | | 1.0 | - | 8.6 |
| Super Ghouls 'N Ghosts (Virtual Console, Classic Mini, Switch Online) | | 1.0 | - | 10.0 |
| Super Goal! 2 | | 1.0 | - | 6.8 |
| Super Goal! 2 (Evercade) | | 1.0 | - | none |
| Super Godzilla | | 1.0 | - | 7.3 |
| Super High Impact | | 1.0 | - | 8.6 |
| Super James Pond | | 1.0 | - | 6.7 |
| Super Mario All-Stars | | 1.0 | - | 8.7 |
| Super Mario All-Stars (Switch Online) | | 1.0 | - | 9.8 |
| Super Mario All-Stars (Wii) | | 1.0 | - | 9.0 |
| Super Mario All-Stars + Super Mario World | | 1.0 | - | 8.6 |
| Super Mario Kart | | 1.0 | - | 8.8 |
| Super Mario RPG: Legend of the Seven Stars | | 1.0 | - | 8.7 |
| Super Mario RPG: Legend of the Seven Stars (Virtual Console) | | 1.0 | - | 9.3 |
| Super Mario World | | 1.0 | - | 8.8 |
| Super Mario World (Virtual Console, Classic Mini, Switch Online) | | 1.0 | - | 9.3 |
| Super Mario World 2: Yoshi's Island | | 1.1 | - | 8.7 |
| Super Metroid | | 1.0 | en ja | 8.7 |
| Super Metroid (Virtual Console, Classic Mini, Switch Online) | | 1.0 | en ja | 10.0 |
| Super Ninja Boy | | 1.0 | - | 8.6 |
| Super Nova | | 1.0 | - | 7.0 |
| Super Off Road | | 1.0 | - | 7.9 |
| Super Off Road: The Baja | | 1.0 | - | 7.6 |
| Super Pinball: Behind the Mask | | 1.1 | - | 8.0 |
| Super Play Action Football | | 1.0 | - | 6.0 |
| Super Probotector: Alien Rebels (Contra Anniversary Collection) | | 1.0 | - | 10.0 |
| Super Punch-Out!! | | 1.0 | - | 8.7 |
| Super Punch-Out!! (GameCube) | | 1.0 | - | 9.0 |
| Super Putty | | 1.0 | - | 7.5 |
| Super Puyo Puyo 2 (Switch Online) | | 1.0 | ja | 10.0 |
| Super R-Type | | 1.0 | - | 7.8 |
| Super R.B.I. Baseball | | 1.0 | - | 7.0 |
| Super Scope 6 | | 1.0 | - | 8.1 |
| Super Slam Dunk | | 1.0 | - | 4.9 |
| Super Slap Shot | | 1.0 | - | 7.8 |
| Super Smash T.V. | | 1.0 | - | 8.7 |
| Super Soccer | | 1.0 | - | 8.7 |
| Super Soccer (Arcade) | | 1.0 | - | none |
| Super Soccer Champ | | 1.0 | - | 5.5 |
| Super Solitaire | | 1.0 | de en es fr it | 3.3 |
| Super Star Fox Weekend (Competition Cart, Nintendo Power mail-order) | | 1.0 | - | 10.0 |
| Super Star Wars | | 1.1 | - | 8.9 |
| Super Star Wars: Return of the Jedi | | 1.1 | - | 8.5 |
| Super Star Wars: The Empire Strikes Back | | 1.1 | - | 8.9 |
| Super Street Fighter II | | 1.1 | - | 8.6 |
| Super Street Fighter II (Virtual Console) | | 1.1 | - | none |
| Super Strike Eagle | | 1.0 | - | 7.5 |
| Super Tennis | | 1.0 | - | 8.6 |
| Super Tennis (Arcade) | | 1.0 | - | none |
| Super Troll Islands | | 1.0 | - | 4.8 |
| Super Turrican | | 1.0 | - | 8.2 |
| Super Turrican (Virtual Console) | | 1.0 | - | none |
| Super Turrican 2 | | 1.0 | - | 7.0 |
| Super Turrican 2 Special Edition (Strictly Limited Games) | | 1.0 | - | none |
| Super Turrican Collection (Strictly Limited Games) | | 1.0 | - | none |
| Super Turrican Collection (Strictly Limited Games) (Alt) | | 1.0 | - | none |
| Super Valis IV | | 1.0 | - | 8.8 |
| Super Widget | | 1.0 | - | 8.8 |
| Suzuka 8 Hours | | 1.0 | - | 7.3 |
| SWAT Kats: The Radical Squadron | | 1.0 | - | 7.9 |
| Syndicate | | 1.0 | - | 8.6 |
